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Modern studies have shown that immune cells play an important role in the occurrence and development of ischemic stroke（IS）. Currently，the intrinsic mechanism of the theory of positive Qi-evil in traditional Chinese medicine（TCM）has not been elucidated yet，and a number of studies have suggested that immune cell-mediated immune homeostasis may be one of the important mechanisms of the theory of positive Qi-evil in TCM. In this paper，it used Mendelian randomization（MR）analysis to verify the causal relationship of immune cells on ISand further explored the intrinsic mechanism of the theory of positive Qi-evil.
Based on publicly available genetic data，a two-sample MR analysis was performed using immune cells as instrumental variables to explore the causal relationship between 731 immune cell phenotypes and the risk of IS prevalence. The inverse variance weighting（IVW）method as the primary method was used as a standardized analysis，supplemented by the use of weighted median，MR-Egger，Simple mode and Weighted mode. Cochrans Q was used to test the heterogeneity，and MR-Egger intercept to test the test-level pleiotropy.
Eleven immune cell phenotypes were still found to be statistically significant（P<0.05 corrected for FDR）：among them CD27 on memory B cell，CD27 on sw mem，CD27 on CD24＋CD27＋，CD27 on IgD-CD38dim，CD27 on IgD-CD38-，CD27 on IgD-CD38br，CD25 on IgD＋and CD25 on IgD＋CD38dim play a dangerous role for IS；CD40 on CD14-CD16＋monocyte，CD40 on CD14＋CD16-monocyte and CD40 on CD14＋CD16＋monocyte play a protective role for IS. Eight of them were in the B-cell group and three in the monocyte group. It was significant with CD27 and CD25 on B cells and CD40 on monocytes.
This study confirmed that immune cells play a key role in ISby genetic means，providing some reference for elucidating the intrinsic mechanism of the theory of positive Qi-evil.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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