To analyze the clinical efficacy of Dahuangqi Decoction（大黄芪汤）in the treatment of radioactive xerostomia in head and neck tumors.

Eighty-six patients with radioactive xerostomia in head and neck tumors treated in Bishan Hospital Affiliated to Chongqing Medical University from January 2022 to October 2023 were included as study objects. They were divided into two groups by random number table method. Forty-three patients in the control group received conventional treatment，and the other 43 patients in the observation group received Dahuangqi Decoction. The treatment effect，accumulated dose of different radiotherapy and the changes of salivary volume，dry mouth degree，salivary gland secretion index（ET），salivary amylase（AMS）and epidermal growth factor（EGF）after 3 and 6 months of radiotherapy were compared between the two groups.

The total effective rate of the observation group was 95.35%（41/43），which was much higher than that of the control group（74.72%，32/43），and the difference was significant（P<0.05）. The degree of dry mouth in the observation group was 44.19%（19/43）in grade 1 and 39.53%（17/43）in grade 2，higher than that in the control group［25.58%（11/43）and 18.60%（8/43）］，and 11.63%（5/43）and 4.65%（2/43）in grade 3 to 4，lower than that in the control group［34.88%（15/43）and 20.93%（9/43）］，with significant difference between two groups（P<0.05）. The static salivary secretion of 20 Gy，40 Gy，60 Gy and 10 min after 3 and 6 months after radiotherapy in the observation group was higher than that in the control group，and the anterior salivary gland secretion index after radiotherapy was also lower than that in the control group，and the difference between two groups was significant（P<0.05）. After treatment，the levels of EGFand AMSin the observation group were higher than those in the control group（P<0.05）.

In the treatment of radioactive xerostomia in head and neck tumors，Dahuangqi Decoction can promote the secretion of body fluid，improve the degree of dry mouth，regulate the levels of AMSand EGF，play a better protective role on the salivary glands in the wild，and improve the quality of life of patients.