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Exploring Formation and Intervention of Breast Cancer Based on Theory of “Depression and Toxin Leading to Deficiency”
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Xiaoyu GAO1, 2, 3, Nan NIU1, 2, Dongxiao ZHANG4, Yunhai GAO5, Fei YU1, Suning CHEN1, Wenping WANG3, Ling HAN2, 6, Liang WANG2, 6, Jinhong LENG2, 5, Caigang LIU1, 2
Chinese Archives of Traditional Chinese Medicine | 2025, 43(7) : 58 - 62
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Chinese Archives of Traditional Chinese Medicine | 2025, 43(7): 58-62
• Target on National Project •
Exploring Formation and Intervention of Breast Cancer Based on Theory of “Depression and Toxin Leading to Deficiency”
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Xiaoyu GAO1, 2, 3, Nan NIU1, 2, Dongxiao ZHANG4, Yunhai GAO5, Fei YU1, Suning CHEN1, Wenping WANG3, Ling HAN2, 6, Liang WANG2, 6, Jinhong LENG2, 5, Caigang LIU1, 2
Affiliations
  • 1.Shengjing Hospital of China Medical University,Shenyang 110004,Liaoning,China
  • 2.Liaoning Provincial Tumor Chinese Medicine Multidisciplinary Interdisciplinary Innovation Team,Shenyang 110004,Liaoning,China
  • 3.Liaoning University of Traditional Chinese Medicine,Shenyang 110847,Liaoning,China
  • 4.Beijing Hospital of Traditional Chinese Medicine,Beijing 100010,China
  • 5.Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110032,Liaoning,China
  • 6.China Resources Sanjiu Pharmaceutical Co.,Ltd,Shenzhen 518110,Guangdong,China
Published: 2025-07-10 doi: 10.13193/j.issn.1673-7717.2025.07.013
Outline
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The theory of“depression and toxin leading to deficiency”holds that the pathological products such as dampness,phlegm,heat and blood stasis caused by excessive anger and depression,Qi stagnation,impaired Zang-Fu function,imbalance of internal environment of the body and metabolic disorder of Qi,blood and body fluid are the initiating factors of carcinogenesis. The key pathogenesis of the occurrence and development of breast cancer is“depression-toxin intertwining,spread of cancer toxin,deficiency caused by cancer,and mutual injury of deficiency and toxin”.“Multi-cause intersection and transformation of cancer toxin”is the core driver of breast cancer. Under the background of modern medicine,“heat toxin injuring Yin essence”,“toxin impairing Qi and blood”and“deficiency fire stagnating heat”are the main pathogenesis evolution of breast cancer radiotherapy,chemotherapy and endocrine therapy,respectively.“Driving away pathological factors and leaving body deficiency”and“residual toxin flowing”are closely related to breast cancer surgery and recurrence and metastasis,respectively. Professor LIU Caigang,in view of the complex pathogenesis of“depression and toxin leading to deficiency”of breast cancer and the complications after modern medical intervention,adopted the modern research and development checkpoint therapeutic target database(CKTTD),combined with the theory of traditional Chinese medicine,explored the advantages of anti-cancer traditional Chinese medicine,and carried out the research of traditional Chinese and Western medicine around cancer-related fatigue,chemotherapy resistance,macroscopically adjusting the body's healthy Qi deficiency and depression and microscopically treating the target of cancer toxins. Several medical institutions represented by Shenbailing Granules(参百灵颗粒)have been developed,and a series of large-sample,multi-center,randomized controlled studies have been carried out to form an“efficient,low-toxic,individualized”breast cancer diagnosis and treatment strategy.

breast cancer  /  depression and toxin leading to deficiency  /  pathogenesis of traditional Chinese medicine  /  therapeutic principle and method
高晓宇, 牛楠, 张董晓, 高允海, 于飞, 陈苏宁, 王文萍, 韩凌, 王亮, 冷锦红, 刘彩刚. 基于“郁毒致虚”理论探讨乳腺癌的形成与干预. 中华中医药学刊, 2025 , 43 (7) : 58 -62 . DOI: 10.13193/j.issn.1673-7717.2025.07.013
Xiaoyu GAO, Nan NIU, Dongxiao ZHANG, Yunhai GAO, Fei YU, Suning CHEN, Wenping WANG, Ling HAN, Liang WANG, Jinhong LENG, Caigang LIU. Exploring Formation and Intervention of Breast Cancer Based on Theory of “Depression and Toxin Leading to Deficiency”[J]. Chinese Archives of Traditional Chinese Medicine, 2025 , 43 (7) : 58 -62 . DOI: 10.13193/j.issn.1673-7717.2025.07.013
Year 2025 volume 43 Issue 7
33
12
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doi: 10.13193/j.issn.1673-7717.2025.07.013
  • Online Date:2026-10-30
  • Published:2025-07-10
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Affiliations
    1.Shengjing Hospital of China Medical University,Shenyang 110004,Liaoning,China
    2.Liaoning Provincial Tumor Chinese Medicine Multidisciplinary Interdisciplinary Innovation Team,Shenyang 110004,Liaoning,China
    3.Liaoning University of Traditional Chinese Medicine,Shenyang 110847,Liaoning,China
    4.Beijing Hospital of Traditional Chinese Medicine,Beijing 100010,China
    5.Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110032,Liaoning,China
    6.China Resources Sanjiu Pharmaceutical Co.,Ltd,Shenzhen 518110,Guangdong,China
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表12种不同金属材料的力学参数
科
Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)
属
Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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