Full
Outline
Traditional Chinese Medicine（TCM）has the unique advantages of multi-efficacy，multi-target and multieffect mechanism，and has a long history in anti-cancer and anti-tumor treatment. As the limitations of western medicine in the treatment of cancer continue to highlight，the monomer and compound active ingredients of TCM have been widely concerned in the field of biomolecular and pharmacological research. More and more research evidence shows that the flavonoids of TCM have more aspects，more ways and significant anti-hepatoma effect. It mainly plays an anti-hepatoma effect by regulating the apoptosis and autophagy of liver cancer cells，inhibiting the invasion and migration of liver cancer cells，anti-angiogenesis of liver cancer cells，regulating the cell cycle arrest of liver cancer cells and reshaping the microenvironment of immunosuppressed liver cancer cells. This article systematically reviewed the domestic and foreign literature on the anti-hepatocellular carcinoma mechanism of flavonoids in TCM，and expounded the phosphatidylinositol 3-kinase（PI3K）/protein kinase B（AKT）/mammalian target of rapamycin（mTOR）signaling pathway，Janus kinase（JAK）/signal transducer and activator of transcription（STAT）signaling pathway and Wnt/β-catenin signaling pathway involved in the proliferation，invasion，migration，transcription，drug resistance and other effects of liver cancer，in order to provide a theoretical basis for the treatment of liver cancer by flavonoids in TCM. Clarifying the multiple pharmacological mechanisms of active ingredients in TCM can provide new thinking and opportunities for cancer treatment strategies and new drug development，and bring benefits to more clinical cancer patients.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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