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Discussion on Internal Relationship between Theory of“Deficiency of Yang Qi，Deficiency and Cold of Spleen and Kidney”and Age-Related Diseases Based on ferroptosis and Research Progress in Application of Fuzi（Aconiti Lateralis Radix Praeparata）
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Meiling ZHANG, Qige WANG, Jie WANG, Xueying QIU, Nan SONG, Guoyuan SUI, Jia WANG, Lianqun JIA
Chinese Archives of Traditional Chinese Medicine | 2025, 43(4) : 105 - 108
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Chinese Archives of Traditional Chinese Medicine | 2025, 43(4): 105-108
• Target on National Project •
Discussion on Internal Relationship between Theory of“Deficiency of Yang Qi，Deficiency and Cold of Spleen and Kidney”and Age-Related Diseases Based on ferroptosis and Research Progress in Application of Fuzi（Aconiti Lateralis Radix Praeparata）
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Meiling ZHANG, Qige WANG, Jie WANG, Xueying QIU, Nan SONG, Guoyuan SUI, Jia WANG, Lianqun JIA
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  • Ministry of Education Key Laboratory of Visceral Phenomenon Theory and Application in Traditional Chinese Medicine, Liaoning University of Traditional Chinese Medicine, Shenyang 110847, Liaoning, China
Published: 2025-04-10 doi: 10.13193/j.issn.1673-7717.2025.04.017
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Aging is a biological process in which cells continue to lose and tissue and organ functions gradually undergo degenerative changes. In this process，a class of diseases whose incidence rate increases exponentially with age are called age-related diseases（ARDs）. In middle age，the gradual decline of Yangqi，spleen deficiency，kidney deficiency and coldness are the key pathological mechanisms for the occurrence of ARDS. Ferroptosis belongs to iron dependent non apoptotic programmed death. Age related iron homeostasis and redox imbalance make it a key link in the occurrence and development of ARDs. It is an important part of the modern biological connotation of treating ARDs from spleen and kidney，including the correlation between“deficiency of spleen Yang，lack of transportation”and mitochondrial iron homeostasis imbalance，and the correlation between“deficiency of kidney Yang，loss of vital Qi”and redox imbalance. Taking ferroptosis as the breakthrough point，this article enriched the understanding of traditional Chinese medicine theory on ARDs，and summarized the progress of Fuzi（Aconiti Lateralis Radix Praeparata）in clinical and basic research in recent years，aiming to provide new thinking for the study of the mechanism of traditional Chinese medicine and western medicine of ARDs.

age-related diseases  /  deficiency of Yang，deficiency and cold of spleen and kidney  /  ferroptosis mechanism  /  Fuzi（Aconiti Lateralis Radix Praeparata）
张美菱, 王琪格, 王杰, 裘雪莹, 宋囡, 隋国媛, 王佳, 贾连群. 基于铁死亡探讨“阳气亏虚，脾肾虚冷”与年龄相关疾病内在联系及附子的应用相关研究进展. 中华中医药学刊, 2025 , 43 (4) : 105 -108 . DOI: 10.13193/j.issn.1673-7717.2025.04.017
Meiling ZHANG, Qige WANG, Jie WANG, Xueying QIU, Nan SONG, Guoyuan SUI, Jia WANG, Lianqun JIA. Discussion on Internal Relationship between Theory of“Deficiency of Yang Qi，Deficiency and Cold of Spleen and Kidney”and Age-Related Diseases Based on ferroptosis and Research Progress in Application of Fuzi（Aconiti Lateralis Radix Praeparata）[J]. Chinese Archives of Traditional Chinese Medicine, 2025 , 43 (4) : 105 -108 . DOI: 10.13193/j.issn.1673-7717.2025.04.017
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Year 2025 volume 43 Issue 4
36
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doi: 10.13193/j.issn.1673-7717.2025.04.017
  • Online Date：2026-10-30
  • Published：2025-04-10
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    Ministry of Education Key Laboratory of Visceral Phenomenon Theory and Application in Traditional Chinese Medicine, Liaoning University of Traditional Chinese Medicine, Shenyang 110847, Liaoning, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
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Genus		 种数
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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