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Anti-tumour Mechanism of Astragaloside Ⅳ and Its Research Progress in Lung Cancer
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Zhenyao YANG1, Xiaoqing ZHANG2, Chengzhi WANG1, Shan ZAHNG1, Gelei ZHAO1, Peimin LIU1, Dongdong LI1
Chinese Archives of Traditional Chinese Medicine | 2025, 43(4) : 187 - 192
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Chinese Archives of Traditional Chinese Medicine | 2025, 43(4): 187-192
• Target on National Project •
Anti-tumour Mechanism of Astragaloside Ⅳ and Its Research Progress in Lung Cancer
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Zhenyao YANG1, Xiaoqing ZHANG2, Chengzhi WANG1, Shan ZAHNG1, Gelei ZHAO1, Peimin LIU1, Dongdong LI1
Affiliations
  • 1.The Second Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450002, Henan, China
  • 2.The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan, China
Published: 2025-04-10 doi: 10.13193/j.issn.1673-7717.2025.04.030
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Cancer is the second leading cause of death worldwide，and lung cancer is one of the malignant tumours with the fastest growing morbidity and mortalit and the greatest threat to people＇s health and lives. In recent years，the research on active ingredients of traditional Chinese medicine to prevent and treat tumours has become more and more in-depth. Huangqi（Astragali Radix）is one of the commonly used anti-tumour Chinese medicines，which has been used in medicine for more than 2000 years，and has been regarded as“the most important medicine for replenishing Qi and spleen”. Astragaloside Ⅳ（AS-Ⅳ）is one of the main active ingredients of Huangqi（Astragali Radix），and modern pharmacological studies have shown that AS-Ⅳ has anticancer，anti-inflammatory，antioxidant and immunomodulatory effects. This paper reviewed the research progress of AS-Ⅳ in lung cancer by collecting and summarizing the mechanisms of AS-Ⅳ in inhibiting tumor cell proliferation，inducing tumor cell apoptosis，inhibiting tumor cell migration and invasion，suppressing epithelial-mesenchymal transition（EMT），regulating autophagy，modulating immune response，alleviating toxic side effects during tumor treatment and enhancing sensitivity to antitumor drugs. The aim was to provide a reference for further research，development and application of AS-Ⅳ in order to support its clinical use.

astragalosideⅣ  /  lung cancer  /  mechanism of action
杨振耀, 张晓青, 王成志, 张山, 赵戈蕾, 刘培民, 李东东. 黄芪甲苷抗肿瘤机制及其在肺癌中的研究进展. 中华中医药学刊, 2025 , 43 (4) : 187 -192 . DOI: 10.13193/j.issn.1673-7717.2025.04.030
Zhenyao YANG, Xiaoqing ZHANG, Chengzhi WANG, Shan ZAHNG, Gelei ZHAO, Peimin LIU, Dongdong LI. Anti-tumour Mechanism of Astragaloside Ⅳ and Its Research Progress in Lung Cancer[J]. Chinese Archives of Traditional Chinese Medicine, 2025 , 43 (4) : 187 -192 . DOI: 10.13193/j.issn.1673-7717.2025.04.030
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Year 2025 volume 43 Issue 4
28
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doi: 10.13193/j.issn.1673-7717.2025.04.030
  • Online Date：2026-10-30
  • Published：2025-04-10
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    1.The Second Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450002, Henan, China
    2.The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
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Genus		 种数
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Percentage of total
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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