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Research Progress on Mechanism of Huangqi（Astragali Radix）Intervention in Peritoneal Fibrosis
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Xiangyu DENG1, Lifeng MENG2, Shaohua ZHOU1, Boxian CHEN1, Xuyu WANG1
Chinese Archives of Traditional Chinese Medicine | 2025, 43(4) : 129 - 132
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Chinese Archives of Traditional Chinese Medicine | 2025, 43(4): 129-132
• Target on National Project •
Research Progress on Mechanism of Huangqi（Astragali Radix）Intervention in Peritoneal Fibrosis
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Xiangyu DENG1, Lifeng MENG2, Shaohua ZHOU1, Boxian CHEN1, Xuyu WANG1
Affiliations
  • 1.Guangxi University of Chinese Medicine, Nanning 530200, Guangxi, China
  • 2.The First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning 530022, Guangxi, China
Published: 2025-04-10 doi: 10.13193/j.issn.1673-7717.2025.04.020
Outline
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Objective

Huangqi（Astragali Radix）has a good effect in anti peritoneal fibrosis（PF）. Analyzing and summarizing the therapeutic effect and mechanism of Huangqi（Astragali Radix）on PF provides ideas for future research on PF.

Method

The relevant literature on the prevention and treatment of PF by Huangqi（Astragali Radix）was retrieved from databases such as PubMed，CNKI and Wanfang. The pharmacological basis and mechanism of action of Huangqi（Astragali Radix）treating PF were analyzed and summarized.

Result

According to traditional Chinese medicine theory and pharmacological analysis of Huangqi（Astragali Radix）against PF，Huangqi（Astragali Radix）can intervene in the process of PF by regulating inflammation，reducing oxidative stress，inhibiting epithelial to mesenchymal transition（EMT）of peritoneal mesothelial cells（PMC），improving metabolic disorders，regulating PMC apoptosis and regulating pro fibrotic factors.

Conclusion

The active ingredients contained in Huangqi（Astragali Radix）have high anti fibrosis activity，which can protect the integrity of peritoneal structure and function in multiple directions and targets.

Huangqi（Astragali Radix）  /  inflammation  /  oxidative stress  /  EMT  /  metabolic disorders  /  peritoneal fibrosis
邓湘雨, 孟立锋, 周少华, 陈柏先, 王旭宇. 黄芪干预腹膜纤维化作用机制的研究进展. 中华中医药学刊, 2025 , 43 (4) : 129 -132 . DOI: 10.13193/j.issn.1673-7717.2025.04.020
Xiangyu DENG, Lifeng MENG, Shaohua ZHOU, Boxian CHEN, Xuyu WANG. Research Progress on Mechanism of Huangqi（Astragali Radix）Intervention in Peritoneal Fibrosis[J]. Chinese Archives of Traditional Chinese Medicine, 2025 , 43 (4) : 129 -132 . DOI: 10.13193/j.issn.1673-7717.2025.04.020
Appendix
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Year 2025 volume 43 Issue 4
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doi: 10.13193/j.issn.1673-7717.2025.04.020
  • Online Date：2026-10-30
  • Published：2025-04-10
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    1.Guangxi University of Chinese Medicine, Nanning 530200, Guangxi, China
    2.The First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning 530022, Guangxi, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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