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Outline
The correlation between the occurrence of diuretic resistance in chronic heart failure and traditional Chinese medicine（TCM）syndrome score was explored and the prevention of diuretic resistance in chronic heart failure and the reference basis for diagnosis and treatment were provided.
The data of hospitalized patients from2020 to 2022 was collected and stratified into two cohorts：those with diuretic resistance（154 cases）and those without diuretic resistance（265 cases）. Chi-square test and T-test were employed to compare the general data between the two groups. Logistic regression and Lasso regression were utilized to investigate the correlation between TCM syndrome score and diuretic resistance.
From 2020 to 2022，a total of 756 inpatients diagnosed with chronic heart failure were enrolled from sample hospitals. Among them，419 patients met the inclusion criteria，including 154 cases with diuretic resistance and 265 cases without diuretic resistance. Both groups received standard treatment consisting of traditional Chinese and Western medicine. There were no significant differences between the two groups in age，sex，cardiac function grade or combined diseases（P>0.05）and the two groups were comparable. The total admission score of the diuretic resistance group［（17.43±4.19）point］was significantly higher than that of the non-diuretic resistance group［（15.80±5.10）point］. Logistic regression model comparison showed that the scores of dyspnea（OR：1.359，95%CI：1.109～1.666），chest tightness and palpitation（OR：1.333，95%CI：1.092～1.628）and hypuria and limb swelling（OR：1.245，95%CI：1.105～1.404）at admission）was a risk factor for diuretic resistance when the patient was admitted. Las-so regression showed that the scores of dyspnea and hypuria and limb swelling were strongly correlated with diuretic resistance.
There is a correlation between diuretic resistance and TCM syndrome score in chronic heart failure. Patients'symptoms should be paid attention to and TCM syndrome score should be accurately evaluated when admitted to hospital.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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