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Research Progress on Intervention of Flavonoids in Polycystic Ovary Syndrome（PCOS）with HPO Axis Disorder
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Quanyang LI1, Guotai WU1, 2, Ruiqiong Wang1, 2
Chinese Archives of Traditional Chinese Medicine | 2025, 43(2) : 146 - 152
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Chinese Archives of Traditional Chinese Medicine | 2025, 43(2): 146-152
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Research Progress on Intervention of Flavonoids in Polycystic Ovary Syndrome（PCOS）with HPO Axis Disorder
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Quanyang LI1, Guotai WU1, 2, Ruiqiong Wang1, 2
Affiliations
  • 1.College of Pharmacy，Gansu University of Chinese Medicine，Lanzhou 730000，Gansu，China
  • 2.Key Laboratory of Pharmacology and Toxicology for Traditional Chinese Medicine of Gansu Province，Lanzhou 730000，Gansu，China
Published: 2025-02-10 doi: 10.13193/j.issn.1673-7717.2025.02.032
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Polycystic ovary syndrome（PCOS）is a reproductive endocrine metabolic disease characterized by endocrine abnormalities，with menstrual disorders，infertility and hirsutism as the main clinical manifestations，seriously affecting the reproductive health of patients. The hypothalamic-pituitary-ovarian axis（HPO axis）has secretion abnormalities in PCOS，such as abnormal pulse frequency of gonadotropin releasing hormone（GnRH），the increased ration of luteinizing hormone（LH）/folliclestimulating hormone（FSH），adrenal and ovarian androgen overproduction. In recent years，traditional Chinese medicine（TCM）has been widely used in the prevention and treatment of PCOSand has shown positive therapeutic effects. Flavonoids，one of the common active ingredients in Chinese medicine，can improve the hormone disorders in the HPO axis of PCOSthrough anti-inflammatory，antioxidant，autophagy and apoptosis pathways，and modulation of the PI3K/AKT pathway，the TGF-β1/Smad pathway，the MAPK/ERK pathway and so on. This article reviewed and analyzed the mechanisms of flavonoids in the treatment of HPO axis secretion disorders in PCOSin recent years，and provided theoretical references for their further development and treatment of PCOS.

PCOS  /  HPO axis  /  flavonoids  /  mechanism of action
李泉洋, 吴国泰, 王瑞琼. 中药黄酮类成分干预多囊卵巢综合征下丘脑-垂体-卵巢轴分泌紊乱的研究进展. 中华中医药学刊, 2025 , 43 (2) : 146 -152 . DOI: 10.13193/j.issn.1673-7717.2025.02.032
Quanyang LI, Guotai WU, Ruiqiong Wang. Research Progress on Intervention of Flavonoids in Polycystic Ovary Syndrome（PCOS）with HPO Axis Disorder[J]. Chinese Archives of Traditional Chinese Medicine, 2025 , 43 (2) : 146 -152 . DOI: 10.13193/j.issn.1673-7717.2025.02.032
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Year 2025 volume 43 Issue 2
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doi: 10.13193/j.issn.1673-7717.2025.02.032
  • Online Date：2026-10-30
  • Published：2025-02-10
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    1.College of Pharmacy，Gansu University of Chinese Medicine，Lanzhou 730000，Gansu，China
    2.Key Laboratory of Pharmacology and Toxicology for Traditional Chinese Medicine of Gansu Province，Lanzhou 730000，Gansu，China
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多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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