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Mechanism of Damp-Heat Syndrome of HIV/AIDS Based on Gene and Proteomics Techniques
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Juan WANG1, Miao ZHANG1, Sa LIU1, Suna MA1, Haiyan ZHANG1, Qianlei XU2
Chinese Archives of Traditional Chinese Medicine | 2025, 43(2) : 72 - 75
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Chinese Archives of Traditional Chinese Medicine | 2025, 43(2): 72-75
• Target on National Project •
Mechanism of Damp-Heat Syndrome of HIV/AIDS Based on Gene and Proteomics Techniques
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Juan WANG1, Miao ZHANG1, Sa LIU1, Suna MA1, Haiyan ZHANG1, Qianlei XU2
Affiliations
  • 1.Henan University of Chinese Medicine，Zhengzhou 450046，Henan，China
  • 2.The First Affiliated Hospital of Henan University of Chinese Medicine，Zhengzhou 450000，Henan，China
Published: 2025-02-10 doi: 10.13193/j.issn.1673-7717.2025.02.016
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Objective

To explore the molecular mechanism of damp-heat syndrome in acquired immune deficiency syndrome（AIDS）.

Method

Agilent gene expression profile chip and iTRAQ-MStechnology were used to perform genomic and proteomic tests on human immunodeficiency virus（HIV）/AIDSpatients with damp-heat syndrome. A total of 20 differentially expressed genes of HIV/AIDSdamp-heat syndrome were identified with ratio change≥1.15 or≤0.87 and P<0.05 as the criteria. There were 22 differentially expressed proteins.

Results

Compared with those of the healthy control group，the expressions of CXCR4，NF-κBIA，TRIB1 and other genes increased，while the expression of CX3CR1 decreased. The expressions of APOA-Ⅱ，CRP，PF4 and AAT were increased，while the expressions of CFB and Gelsolin were decreased.

Conclusion

HIV/AIDSdampheat syndrome is closely related to inflammation. HIV/AIDS damp-heat syndrome has its specific molecular biological basis，which provides methods and basis for the objectization and standardization of traditional Chinese medicine.

HIV/AIDS  /  damp-heat syndrome  /  immunity gene
王娟, 张淼, 刘飒, 马素娜, 张海燕, 许前磊. 基于基因及蛋白组学技术探讨HIV/AIDS湿热证的作用机制. 中华中医药学刊, 2025 , 43 (2) : 72 -75 . DOI: 10.13193/j.issn.1673-7717.2025.02.016
Juan WANG, Miao ZHANG, Sa LIU, Suna MA, Haiyan ZHANG, Qianlei XU. Mechanism of Damp-Heat Syndrome of HIV/AIDS Based on Gene and Proteomics Techniques[J]. Chinese Archives of Traditional Chinese Medicine, 2025 , 43 (2) : 72 -75 . DOI: 10.13193/j.issn.1673-7717.2025.02.016
Appendix
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Year 2025 volume 43 Issue 2
34
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doi: 10.13193/j.issn.1673-7717.2025.02.016
  • Online Date：2026-10-30
  • Published：2025-02-10
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    1.Henan University of Chinese Medicine，Zhengzhou 450046，Henan，China
    2.The First Affiliated Hospital of Henan University of Chinese Medicine，Zhengzhou 450000，Henan，China
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表12种不同金属材料的力学参数
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Family		 属数
Number of
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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