Full
Outline
This study was aimed to investigate effects of baicalin on ovarian glycometabolism process in aged mice.
Female ICR mice at the age of 10 months old were selected as the aged model，and were divided into the aged control group and baicalin group. Meanwhile，the mice aged 7 weeks old were set as the young control. The aged mice were orally administrated with 25 mg/kg baicalin，once a day for continuous 30 days. The other groups were orally administrated with the same dose of physiological saline solution. After the end of the experiments，peripheral blood，ovaries，liver，kidney and spleen of mice of each group were collected for assays of enzyme activities of glycometabolism key rate-limiting enzymes and expression levels of pro-apoptotic proteins as well as phosphatidylinositol-3-kinase/protein kinase B/mammalian target of rapamycin（PI3K/AKT/mTOR）pathway.
The results showed that compared with those of the aged control，the general clinical manifestations of the aged mice with baicalin treatment were normal，the levels of serum follicle-stimulating hormone（FSH）diseased（P<0.05），the level of serum estradiol（E2）increased（P<0.05），the activity of glycometabolism key rate-limiting enzymes enhanced（P<0.001），the expressions of pro-apoptosis protein including BCL2 associated X protein（BAX）and cysteine aspartate-specific protease-3（Caspase-3）were inhibited and the expressions of PI3K，AKT，mTOR and their phosphorylated forms were suppressed.
These data above indicated that baicalin can regulate activities of glycometabolism key ratelimiting enzymes and expressions of pro-apoptotic proteins through PI3K/AKT/mTOR pathway，so as to improve ovarian aging.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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