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Changes of Bradykinin and Interleukin-1β in Patients with Chronic Frozen Shoulder Treated with Modified Shentong Zhuyu Decoction(身痛逐瘀汤加味)Assisting Tuina Therapy
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Jun YU, Wenjun KUI, Chunchun XUE, Zhen GU, Lei XIE, Aiping HUANG, Shuyi KONG, Kaiqiang WANG
Chinese Archives of Traditional Chinese Medicine | 2025, 43(2) : 88 - 91
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Chinese Archives of Traditional Chinese Medicine | 2025, 43(2): 88-91
• Target on National Project •
Changes of Bradykinin and Interleukin-1β in Patients with Chronic Frozen Shoulder Treated with Modified Shentong Zhuyu Decoction(身痛逐瘀汤加味)Assisting Tuina Therapy
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Jun YU, Wenjun KUI, Chunchun XUE, Zhen GU, Lei XIE, Aiping HUANG, Shuyi KONG, Kaiqiang WANG
Affiliations
  • Shanghai Municipal Hospital of Traditional Chinese Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 200071,China
Published: 2025-02-10 doi: 10.13193/j.issn.1673-7717.2025.02.020
Outline
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Objective

To study the effect of Modified Shentong Zhuyu Decoction(身痛逐瘀汤加味)assisting Tuina therapy for chronic frozen shoulder on the changes of bradykinin(BK)and interleukin-1β(IL-1β)in patients.

Methods

One hundred patients with chronic frozen shoulder admitted to the Shanghai Municipal Hospital of Traditional Chinese Medicine Affiliated to Shanghai University of Traditional Chinese Medicine from May 2022 to April 2023 were selected,and were divided into the Tuina group and the Modified Shentong Zhuyu Decoction group by the randomized numerical method. The Tuina group was treated with Tuina therapy,and the Modified Shentong Zhuyu Decoction group was treated with Modified Shentong Zhuyu Decoction on the basis of Tuina therapy,and the clinical effects of the two groups were analyzed.

Results

The total effective rate was 96.00%(clinical cure rate 28.00% +significant effect rate 42.00% +effective rate 26.00%)in the Modified Shentong Zhuyu Decoction group was higher than that(84.00%)(clinical cure rate 18.00%+significant effect rate 36.00%+effective rate 30.00%)in the Tuina group,with a significant difference(P<0.05). Before treatment,there was no difference in bradykinin(BK),5-hydroxytryptamine(5-HT)or inflammatory factors between the Tuina group and the Modified Shentong Zhuyu Decoction group(P>0.05). The levels of BK,interleukin-18(IL-18),5-HT,IL-1β,interleukin-32(IL-32)and granulocyte-macrophage colony-stimulating factor(GM-CSF)were lower in the Tuina and Modified Shentong Zhuyu Decoction groups compared with those before treatment(P<0.05),and they were lower in the Modified Shentong Zhuyu Decoction group compared with those in the Tuina group(P<0.05). Before treatment,there was no difference between the McGill Pain Questionnaire score and American Shoulder and Elbow Surgeons'Score(ASES)in the Tuina group and the Modified Shentong Zhuyu Decoction group(P>0.05). McGill scores were lower in the Tuina and Modified Shentong Zhuyu Decoction groups than those before treatment(P<0.05),and lower in the Modified Shentong Zhuyu Decoction group than those in the Tuina group(P<0.05). ASESscores were lower(P<0.05)in the Tuina and Modified Shentong Zhuyu Decoction groups than those before treatment,and the score in the Modified Shentong Zhuyu Decoction group higher(P<0.05)than that in the Tuina group.

Conclusion

Modified Shentong Zhuyu Decoction assisting Tuina therapy for chronic frozen shoulder can reduce the expressions of BK,5-HT and Inflammatory Factors and improve the daily living ability.

Modified Shentong Zhuyu Decoction(身痛逐瘀汤加味)  /  Tuina therapy  /  chronic periarthritis of shoulder  /  bradykinin  /  inflammatory factor
虞隽, 蒉文筠, 薛纯纯, 谷桢, 谢磊, 黄爱苹, 孔舒祎, 王开强. 身痛逐瘀汤加味辅以推拿疗法治疗慢性肩周炎疗效及对缓激肽、白细胞介素-1β变化的研究. 中华中医药学刊, 2025 , 43 (2) : 88 -91 . DOI: 10.13193/j.issn.1673-7717.2025.02.020
Jun YU, Wenjun KUI, Chunchun XUE, Zhen GU, Lei XIE, Aiping HUANG, Shuyi KONG, Kaiqiang WANG. Changes of Bradykinin and Interleukin-1β in Patients with Chronic Frozen Shoulder Treated with Modified Shentong Zhuyu Decoction(身痛逐瘀汤加味)Assisting Tuina Therapy[J]. Chinese Archives of Traditional Chinese Medicine, 2025 , 43 (2) : 88 -91 . DOI: 10.13193/j.issn.1673-7717.2025.02.020
Year 2025 volume 43 Issue 2
38
17
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doi: 10.13193/j.issn.1673-7717.2025.02.020
  • Online Date:2026-10-30
  • Published:2025-02-10
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    Shanghai Municipal Hospital of Traditional Chinese Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 200071,China
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表12种不同金属材料的力学参数
科
Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)
属
Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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