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Outline
Dysfunction of circadian rhythms can induce ferroptosis by affecting the expressions of clock genes. According to the holographic theory of traditional Chinese medicine，each cell in the body is regarded as a microcosm of the entire body. The source，distribution and function of iron in cells are similar to those of nutrient Qi，and mitochondria are similar to those of defensive Qi. Moreover，the function of nutrient Qi is controlling the opening and closing of the cell membrane. It is speculated that nutrient Qi and defensive Qi inhibit the process of cell ferroptosis by balancing intracellular iron content and improving mitochondrial morphology and cell membrane structure，and the main mechanism of ferroptosis is the decline of mitochondrial structure and function caused by iron overload and membrane damage，indicating that the deficiency of defensive Qi caused by excessive nutrient Qi is a traditional Chinese medicine pathogenesis of ferroptosis induced by biological clock disorder. The liver's function of regulating blood circulation and storing blood plays a role in regulating the circulation of Qi and promoting the production of blood. It can be seen that treating liver can effectively improve iron death induced by the disturbance of the biological clock by regulating nutrient Qi and defensive Qi.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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