To observe the clinical effect of Maxing Shigan Decoction（麻杏石甘汤）combined with amoxicillin sodium and clavulanate potassium in the treatment of children with pulmonary infection and its influence on inflammation and other indicators.

A total of 85 children with pulmonary infection were included in the study，all of whom were admitted to the Department of Pediatrics of the hospital from December 2020 to February 2023，meeting the diagnosis of pulmonary infection. The children were divided into control group（42 cases）and observation group（43 cases）by random number table method，and the control group was treated with amoxicillin sodium and clavulanate potassium. The children in the observation group were treated with amoxicillin sodium clavulanate potassium combined with Maxing Shigan Decoction. During the treatment，1 case fell off in the control group and 2 cases fell off in the observation group. The data of children in each group was observed，including treatment effect，fever disappearance time，lung infection absorption time，cough relief time，heart rate respiratory recovery time and the time of disappearance of lung rales，the scores of traditional Chinese medicine symptoms（cough，asthma，expectoration，fever，irritability，etc.）changes before and after treatment，changes of inflammatory factor indicators and lung function indicators，changes of oxygenation index and lung infection score，length of hospital stay and adverse reactions.

The treatmenteffectof the observation group was better than that of control group（P<0.05）. Compared with those of the control group，the disappearance time of fever，absorption time of pulmonary infection，cough relief time，heart rate and respiration recovery time and the disappearance time of lung rales in observation group were shorter（P<0.05）. The levels of tumor necrosis factor-α（TNF-α），interleukin 6（IL-6），interleukin 8（IL-8）and other inflammatory markers，the scores of TCM symptoms（cough，asthma，phlegm，fever，irritability，etc.）in each group before treatment，forced vital capacity，FVC，forced expiratory volume in one second（FEV1）and other pulmonary function indexes，oxygenation index and pulmonary infection score were not significant（P>0.05）. After treatment，the scores of TCM symptoms（cough，asthma，sputum，fever，irritability，etc.），inflammatory factor indexes（TNF-α，IL-6 and IL-8），pulmonary function indexes（FVC，FEV1），oxygenation index，pulmonary infection score and other indexes were improved in both groups. Those in the observation group were all better than those in the control group after treatment（P<0.05）. The hospitalization time of the observation group was shorter than that of the control group and the hospitalization cost was less than that of control group（P<0.05）. The adverse reaction rate was lower in both groups（P>0.05）.

The therapeutic effect of Maxing Shigan Decoction combined with amoxicillin sodium and clavulanate potassium in the treatment of children with pulmonary infection is accurate. The symptoms of children are improved，with fast recovery and improved lung function. There are fess adverse reactions. The treatment is safe and reliable，and it is worthy of application.