To explore the efficacy of Yishen Tiaogan Decoction（益肾调肝方）on perimenopausal women with dry eye of kidney deficiency and liver depression syndrome and its influence on early changes in ocular surface.

One hundred and twenty perimenopausal women with dry eye of kidney deficiency and liver depression syndrome admitted to the hospital from February 2021 to March 2023 were selected，and randomly assigned into two groups，each with 60 cases. The control group received sodium hyaluronate eye drops. Based on this，the study group was given Yishen Tiaogan Decoction. The treatment in both groups lasted for 4 weeks. Then the TCM symptom scores，ocular surface function［tear film break-up time（BUT），Schirmer I test（SIT），cornea corneal fluorescein（FL）staining］，clinical efficacy，the levels of inflammatory factors［interleukin（IL）-6，IL-33］and adverse reactions were compared between two groups after treatment.

TCM syndrome scores showed a decline in both groups after treatment（P<0.05），and the score was（1.60±0.35）point in the study group，which was lower than that［（4.89±0.74）point］in the control group（P<0.05）. Therewas an improvement in BUT，SIT and FL score in both groups after treatment（P<0.05），and the three parameters were（10.08±1.29）s，（11.25±2.26）mm/5 min and（0.85±0.14）point in the study group，which were all better than those［（5.64±1.15）s，（7.76±1.35）mm/5 min and（2.38±0.49）point］in the control group，with statistical difference（P<0.05）. In the control group，15 cases were cured，24 cases were improved and 21 cases were ineffective. In the study group，35 cases were cured，22 cases were improved and 3 cases were ineffective. The efficacy grade distribution yielded statistical difference between two groups（Z＝-5.044，P<0.05）. The overall efficacy rate was 95.00%（57/60）in the study group，which was higher than that（65.00%，39/60）in the control group（P<0.05）. Serum levels of inflammatory factors showed a decrease in both groups after treatment（P<0.05）. The serum levels of IL-6 and IL-33 were（15.13±3.30）pg/mL and（10.30±1.85）pg/m L in the study group，which were lower than those［（17.26±3.71）pg/mL and（11.49±2.18）pg/mL］in the controlgroup（P<0.05）. During the treatment period，no adverse reactions were found in the control group，and one case of diarrhoea occurred in the study group，the symptoms were mild and could be relieved without any intervention. The adverse reaction rate yielded no statistical difference between two groups（χ²＝1.008，P>0.05）.

Yishen Tiaogan Decoction for perimenopausal women with dry eye of kidney deficiency and liver depression syndrome can effectively alleviate the clinical symptoms，improve ocular surface function and attenuate inflammation response with no significant adverse reactions，which is worthy of recommendation.