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Optimization of Preparation Technology of Danggui(Angelicae Sinensis Radix)Oil Microcapsules by Box-Behnken Response Surface Methodology and Quality Evaluation
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Qingbo MA1, Jiawen GAO1, Xujiang ZHU1, 2, Shixia YAO2, jing LIU1, Yajuan YU1, Jing SHI1
Chinese Archives of Traditional Chinese Medicine | 2025, 43(1) : 147 - 151
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Chinese Archives of Traditional Chinese Medicine | 2025, 43(1): 147-151
• Target on National Project •
Optimization of Preparation Technology of Danggui(Angelicae Sinensis Radix)Oil Microcapsules by Box-Behnken Response Surface Methodology and Quality Evaluation
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Qingbo MA1, Jiawen GAO1, Xujiang ZHU1, 2, Shixia YAO2, jing LIU1, Yajuan YU1, Jing SHI1
Affiliations
  • 1.College of Pharmacy, Gansu University of Chinese Medicine, Lanzhou 730000, Gansu, China
  • 2.Gansu Institute for Drug Control, Lanzhou 730070, Gansu, China
Published: 2025-01-10 doi: 10.13193/j.issn.1673-7717.2025.01.026
Outline
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Objective

To study the preparation of Danggui(Angelicae Sinensis Radix)oilmicrocapsules,screening out the best preparation process and quality evaluation.

Methods

The microcapsules of volatile oil from Danggui(Angelicae Sinensis Radix)were prepared by complex coacervation method with gelatin and gum arabic solution as the materials. Tts quality evaluation was carried out through the appearance,microscopy,electronmicroscopy,particle size and other aspects.

Results

When the concentration of gelatin solution was 3%,the concentration of arabic gum solution was 1%,the proportion of volatile oil to bladdermaterial was 30%,the pH value of complex coacervation reaction was 4.2,the temperature of bladder formation was 40℃,the stirring speed was 600 r·min-1,adding curing agent(5 mL)and curing for 30 min,the encapsulation efficiency was the highest(85.62%). The microcapsulesmade by the optimal technology had good quality.

Conclusion

The microcapsules of Danggui(Angelicae Sinensis Radix)oil prepared by the optimal process have uniform particle size,stable process and good entrapment efficiency.

volatile oil of Danggui(Angelicae Sinensis Radix)  /  microcapsules  /  complex coacervation  /  response surfacemethod  /  preparation process
马庆博, 高嘉雯, 朱旭江, 姚世霞, 刘竞, 于亚娟, 石晶. Box-Behnken响应面法优化当归油微囊的制备工艺及其质量评价. 中华中医药学刊, 2025 , 43 (1) : 147 -151 . DOI: 10.13193/j.issn.1673-7717.2025.01.026
Qingbo MA, Jiawen GAO, Xujiang ZHU, Shixia YAO, jing LIU, Yajuan YU, Jing SHI. Optimization of Preparation Technology of Danggui(Angelicae Sinensis Radix)Oil Microcapsules by Box-Behnken Response Surface Methodology and Quality Evaluation[J]. Chinese Archives of Traditional Chinese Medicine, 2025 , 43 (1) : 147 -151 . DOI: 10.13193/j.issn.1673-7717.2025.01.026
Year 2025 volume 43 Issue 1
28
12
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doi: 10.13193/j.issn.1673-7717.2025.01.026
  • Online Date:2026-10-30
  • Published:2025-01-10
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    1.College of Pharmacy, Gansu University of Chinese Medicine, Lanzhou 730000, Gansu, China
    2.Gansu Institute for Drug Control, Lanzhou 730070, Gansu, China
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表12种不同金属材料的力学参数
科
Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)
属
Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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