To observe the clinical effect and safety of Hushi Yiwei Decoction（胡氏益胃汤）combined with acupuncture in the treatment of chronic atrophic gastritis.

A total of 104 patients with chronic atrophic gastritis（admitted from January 2021 to June 2023）were included for group study. The patients were randomly divided into control group（Furazolidone Tablets and Cisaprid Tablets）and traditional Chinese medicine group（Furazolidone Tablets and Cisaprid Tablets，Hushi Yiwei Decoction and acupuncture）by random number table method，and 52 cases in each group. During the study，3 cases fell off in the traditional Chinese medicine group and 1 case fell off in the control group. The effect，the changes of TCM syndrome scores（epigastric fullness，stomachache and distention）and gastroscopy indexes（degree of enterization，gastric mucosa characteristics and degree of gastric atrophy）before and after treatment，the levels of serum gastrointestinal hormone indexes（gastrin and somatostatin gastrin），the levels of serum inflammatory factors［interleukin-6（IL-6），interleukin-8（IL-8），tumour necrosis factor-α（TNF-α）］，the positive rates of Helicobacter pylori（HP）before and after treatment，the levels of T lymphocytes（CD₄⁺，CD₈⁺，CD₄⁺/CD₈⁺）and adverse reactions were observed.

The treatment effect of the traditional Chinese medicine group was better than that of the control group（P<0.05）. Before treatment，TCM syndrome scores（gastric epigastric fullness and acid belching，abdominal pain and distension），gastroscopy indexes（degree of enterization，gastric mucosa characteristics and degree of gastric atrophy），serum gastrointestinal hormone indexes（motilin，somatostatin and gastrin），serum inflammatory factor levels（IL-6，IL-8 and TNF-α），HP positive rate and immune function indexes（CD₄⁺，CD₈⁺，CD₄⁺/CD₈⁺）of all patients in each group were not significant（P>0.05）. After treatment，TCM syndrome scores（gastric epigastric fullness，acid belching，abdominal pain and distention），gastroscopy indexes（degree of enterification，gastricmucosa characteristics and degree of gastric atrophy），gastrin levels，IL-6，IL-8 and TNF-αlevels，HP positive rate and CD₈⁺ indexes were all decreased in both groups. The levels of motilin and somatostatin，CD₄⁺ and CD₄⁺/CD₈⁺ were increased，and the increase and decrease of all indexes in the traditional Chinese medicine group after treatment were greater than those in the control group（P<0.05）. The adverse reaction rate of traditional Chinese medicine group and control group was lower（P>0.05）.

Hushi Yiwei Decoction combined with acupuncture therapy has significant clinical effect in the treatment of chronic atrophic gastritis，which can effectively relieve the symptoms，alleviate the condition and improve the gastrointestinal function and immune function of patients，reduce the positive rate of HP and the adverse reaction，and is safe and reliable.