To explore the effects of Modified Zhibai Dihuang Pill（知柏地黄丸）combined with acupoint catgutembedding on sex hormones and plasma Kisspeptin levels in girls with idiopathic central precocious puberty.

Seventy-two girls with idiopathic central precocious puberty who received treatment in the hospital from June 2021 to December 2022 were selected as subjects of this study，and were randomly divided into observation group and control group according to random number table method，with 36 cases in each group. The observation group was treated with Modified Zhibai Dihuang Pill combined with acupoint catgut embedding. The control group was treated with lepraline acetate 3.75mg by subcutaneous injection. Growth and development indexes，secondary sex characteristics，sex hormone levels and plasma Kisspept in levels were compared between the two groups.

There were no significant differences in heightand weightbet ween two groups before and after treatment（P>0.05）. The bone age index between two groups before treatment had no significance（P>0.05）. The bone age indexes in the two groups after treatment were significantly lower than those before treatment，and the index in the observation group was significantly lower than that in the control group（P<0.05）. There were no significantdifferences in the diameter of milk nucleus，uterine volume，ovarian volume ormaximum follicle diameter between the two groups before treatment（P>0.05）. After treatment，the diameter ofmilk nucleus，uterine volume，ovarian volume and maximum follicle diameter between the two groups were significantly lower than those before treatment，and the values in the observation group wre significantly lower than those in the control group（P<0.05）. There were no significant differences in the levels of follicular estrogen（FSH），estradiol（E₂）or luteinizing hormone（LH）between the two groups before treatment（P>0.05），and the levels in the two groups after treatment were significantly lower than those before treatment. There was no significant difference in plasma Kisspeptin level between the two groups before treatment（P>0.05），and the plasma Kisspeptin level in the two groups after treatment was significantly lower than that before treatment，and that in the observation group was significantly lower than that in the control group（P<0.05）.

In the treatment of idiopathic central precocious puberty in girls，Zhibai Dihuang Pill combined with acupoint catgut embedding can effectively improve the growth，development and secondary sex characteristics of the children，and reduce the secretion of sex hormones and plasma Kisspeptin.