Full
Outline
With the continuous development of naturalmedicinal chemistry，natural products with good activity in plants are gradually attracting attention，butmost of them are restricted from further development due to their low content，etc. How to increase the content and ensure the quality of natural sources has become an urgent issue. Nobiletin is a natural polymethoxyflavonoid，mainly exists in Citrus aurantium，family Rutaceae，with awide range of biologicalactivities such as anti-tumor，anti-inflammatory，protection and improvement of the nervous system，etc. Ithas gradually become a hotspot for the development of new anti-tumor drugs for its broad spectrum anti-cancer effects againsta variety of cancer cells through multiple pathways. Through reviewing the literature，summarizing the research on nobiletin at home and abroad in recent years，and outlining the current status of research，this paper summed up the factors influencing the content of nobiletin and its antitumormechanism of action from different sources，origins，storage and concoction，and clarified the quality control methods of natural sources，aiming to provide new ideas for further research and development of nobiletin and new antitumor drugs.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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