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Study on Protective Effect and Mechanism of Jiedu Huayu Granules （解毒化瘀颗粒）on Liver Failure in Rats
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Linlin LIU1, Yuwen YANG1, Yuanqian YAO1, Dewen MAO2, Wenfu ZHANG2, Zhe PAN2, Jianlin LYU2
Chinese Archives of Traditional Chinese Medicine | 2025, 43(1) : 69 - 71
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Chinese Archives of Traditional Chinese Medicine | 2025, 43(1): 69-71
• Target on National Project •
Study on Protective Effect and Mechanism of Jiedu Huayu Granules （解毒化瘀颗粒）on Liver Failure in Rats
Full
Linlin LIU1, Yuwen YANG1, Yuanqian YAO1, Dewen MAO2, Wenfu ZHANG2, Zhe PAN2, Jianlin LYU2
Affiliations
  • 1.Guangxi University of Chinese Medicine, Nanning 530001, Guangxi, China
  • 2.The First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning 530023, Guangxi, China
Published: 2025-01-10 doi: 10.13193/j.issn.1673-7717.2025.01.013
Outline
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Objective

To observe the protective effect of Jiedu Huayu Granules（解毒化瘀颗粒）on liver failure in rats and to investigate its mechanism of action.

Methods

Thirty SPF-grade Wistar rats were divided into blank control group，model control group and Jiedu Huayu Granules group（JDHYKL group）according to the number table method，with 10 rats in each group. Dgalactosamine（D-GalN）+lipopolysaccharide（LPS）was used to replicate the ratmodel of acute liver failure，and the JDHYKL group was given Jiedu Huayu Granules by irrigated 5 days beforemodeling and continued until 24 h after modeling，and the blank group and the model control group were given equal amounts of distilled water. The liver function［alanine aminotransferase（ALT），aspartate aminotransferase（AST），total bilirubin（TBil）］，the levels of oxidative stress indexes［malondialdehyde（MDA），superoxide dismutase（SOD），glutathione peroxidase（GSH-PX）］，inflammatory cytokines［interleukin-6（IL-6）and tumor necrosis factorα（TNF-α）］were detected in each group，and the histopathological changes of liver were observed in each group by HE staining.

Results

The hepatocyte necrosis in the liver tissue of rats was significantly improved after treatment with Jiedu Huayu Granules. Meanwhile，it could significantly decrease the levels of ALT，AST，TBil，MDA，IL-6 and TNF-α，and increase the levels of SOD and GSH-PX（P<0.05）.

Conclusion

Jiedu Huayu Granules have significant antioxidant and antiinflammatory effects，and could mitigate hepatocyte necrosis in liver failure.

liver failure  /  Jiedu Huayu Granules（解毒化瘀颗粒）  /  antioxidant  /  anti-inflammation
柳琳琳, 杨玉雯, 姚元谦, 毛德文, 张文富, 潘哲, 吕建林. 解毒化瘀颗粒对肝衰竭大鼠的保护作用及机制研究. 中华中医药学刊, 2025 , 43 (1) : 69 -71 . DOI: 10.13193/j.issn.1673-7717.2025.01.013
Linlin LIU, Yuwen YANG, Yuanqian YAO, Dewen MAO, Wenfu ZHANG, Zhe PAN, Jianlin LYU. Study on Protective Effect and Mechanism of Jiedu Huayu Granules （解毒化瘀颗粒）on Liver Failure in Rats[J]. Chinese Archives of Traditional Chinese Medicine, 2025 , 43 (1) : 69 -71 . DOI: 10.13193/j.issn.1673-7717.2025.01.013
Appendix
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Year 2025 volume 43 Issue 1
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doi: 10.13193/j.issn.1673-7717.2025.01.013
  • Online Date：2026-10-30
  • Published：2025-01-10
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    1.Guangxi University of Chinese Medicine, Nanning 530001, Guangxi, China
    2.The First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning 530023, Guangxi, China
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https://castjournals.cast.org.cn/joweb/zhzyyxk/EN/10.13193/j.issn.1673-7717.2025.01.013
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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