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Discussion on Pathogenesis of Comorbidity of Lumbar Degenerative Disc Disease and Paravertebral Sarcopenia Based on Theory of “Bone and Flesh Not Match”
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Haijian CUI1, 2, Xiaosheng YAO2, Xiaonan QI2, Hongxin ZHENG1, Yu WANG2, Siwei WANG2, Yingtao HUANG1
Chinese Archives of Traditional Chinese Medicine | 2025, 43(1) : 102 - 107
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Chinese Archives of Traditional Chinese Medicine | 2025, 43(1): 102-107
• Target on National Project •
Discussion on Pathogenesis of Comorbidity of Lumbar Degenerative Disc Disease and Paravertebral Sarcopenia Based on Theory of “Bone and Flesh Not Match”
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Haijian CUI1, 2, Xiaosheng YAO2, Xiaonan QI2, Hongxin ZHENG1, Yu WANG2, Siwei WANG2, Yingtao HUANG1
Affiliations
  • 1.Liaoning University of Traditional Chinese Medicine, Shenyang 110847, Liaoning, China
  • 2.The Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang 110032, Liaoning, China
Published: 2025-01-10 doi: 10.13193/j.issn.1673-7717.2025.01.019
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Lumbar degenerative disc disease（LDDD）and sarcopenia are common age-related motor system diseases in the elderly，which seriously affect the health of the elderly. The reduction of paravertebral muscle is the manifestation of sarcopenia in the spine，and clinical findings show the paravertebral sarcopenia and LDDD often present comorbidity status，mutual influence and mutual causality. Basic research suggests that the two have similar pathogenesis and pathological mechanisms. LDDD is mostly treated symptomatically in clinical practice，and there is still a lack of effective means to reverse in tervertebral disc degeneration. The common intervention methods for sarcopenia include resistance exercise and nutritional supplementation，but there is a lack of effective therapeutic drugs. Traditional Chinese medicine（TCM）classifies LDDD as “lumbago” and “spinalgia” and paravertebral sarcopenia as “Wei syndrome” and “consumptive disease”. TCM has a profound understanding of the relationship between the two，and highly summarizes the pathological state of its comorbidity with the theory of “bone and flesh notmatch”. It is believed that the deficiency of spleen and kidney is the common pathogenesis. Tonifying spleen and kidney is the basic treatment method. However，the research on traditional Chinese medicine urgently needs to adopt real-world research to enrich theories and evidence-based medicine research to verify therapeutic effects and basic experimental research to deeply reveal the mechanisms of comorbidities and explain the mechanisms of therapeutic effects，providing new ideas for deepening the relevant theories of traditional Chinese medicine and inventing new drugs.

lumbar degenerative disc disease  /  sarcopenia  /  paravertebral sarcopenia  /  bone and flesh notmatch  /  comorbidity
崔海舰, 姚啸生, 戚晓楠, 郑洪新, 王禹, 王思微, 黄英韬. 基于“骨肉不相亲”理论探讨腰椎间盘退行性疾病与椎旁肌减少症共病机制. 中华中医药学刊, 2025 , 43 (1) : 102 -107 . DOI: 10.13193/j.issn.1673-7717.2025.01.019
Haijian CUI, Xiaosheng YAO, Xiaonan QI, Hongxin ZHENG, Yu WANG, Siwei WANG, Yingtao HUANG. Discussion on Pathogenesis of Comorbidity of Lumbar Degenerative Disc Disease and Paravertebral Sarcopenia Based on Theory of “Bone and Flesh Not Match”[J]. Chinese Archives of Traditional Chinese Medicine, 2025 , 43 (1) : 102 -107 . DOI: 10.13193/j.issn.1673-7717.2025.01.019
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Year 2025 volume 43 Issue 1
49
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doi: 10.13193/j.issn.1673-7717.2025.01.019
  • Online Date：2026-10-30
  • Published：2025-01-10
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    1.Liaoning University of Traditional Chinese Medicine, Shenyang 110847, Liaoning, China
    2.The Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang 110032, Liaoning, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
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Percentage of total
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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