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Outline
Atopic dermatitis (AD) is a common, recurrent immunoinflammatory disease in dermatology characterized by eczematous rash and intense itching. The theory of the “gut-skin axis” suggests a close physiological and pathological relationship between the skin and the gut microbiome. The disorder of the gut bacterial and its metabolic products have been directly and indirectly linked to AD, making the regulation of the gut microbiome a new means of clinical intervention for AD. The traditional Chinese medicine (TCM) theory of “a skin disease indicating an intestinal disease” has already demonstrated the physiological and pathological connection between the intestines and the skin. Subsequently, some scholars have proposed that “skin and intestine affect each other”, advocating the treatment of skin diseases from the perspective of the intestine, namely the AD treatment approach of “treating skin from intestine”. Gegen Qinlian Decoction (葛根芩连汤), a classic formula from the Treatise on Cold Pathogenic Diseases, has proven effect in the clinical treatment of AD and a clear modern pharmacological regulatory effect on the gut microbiome. The treatment of AD with Gegen Qinlian Decoction not only follows the principles of TCM classic formulas, but also expands its application based on objective evidence from modern medicine. This article mainly discussed the feasibility of treating AD with Gegen Qinlian Decoction by regulating the gut microbiome, focusing on the principle of “treating skin from intestine”.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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