To analyze the effect of Modified Simiao Yong'an Decoction (加味四妙勇安汤) combined with acupuncture at sensitized acupoints on platelet function parameters and serum apoptosis factor levels after percutaneous coronary intervention (PCI) for acute coronary syndrome.

A total of 226 patients with acute coronary syndrome who underwent PCI and were admitted to the hospital from January 2022 to December 2024 were included in the study. They were divided into two groups by the random number table method. The patients (113 cases) in the control group were treated with conventional Western medicine after surgery, and those (113 cases) in the observation group were treated with Modified Simiao Yong'an Decoction combined with acupuncture at sensitized acupoints on this basis. The treatment effects, syndrome scores, platelet function parameters, serum apoptosis factor levels and changes in vascular endothelial function were compared between the two groups.

The total effective rate in the observation group was 93.81%(106/113), which was significantly higher than that (77.88%, 88/113) in the control group, and the difference between the two groups was significant (P<0.05). After treatment, the syndrome scores of both groups decreased (P<0.05), and the decrease in the observation group was more significant compared with that in the control group (P<0.05). The levels of platelet aggregation test (PagT), mean platelet volume (MPV) and platelet distribution width (PDW) in both groups decreased, and the platelet count (PLT) increased. The improvement in the observation group was more significant compared with that in the control group (P<0.05). After treatment, the levels of cysteinyl aspartate specific proteinase-3 (Caspase-3) and Bcl-2 associated X protein (Bax) in both groups decreased, and the level of B-cell lymphoma-2 (Bcl-2) increased. The improvement in the observation group was more significant compared with that in the control group (P<0.05). After treatment, the ET-1 level in both groups decreased compared with that before treatment, and the nitric oxide (NO) level increased. The improvement in the observation group was more significant compared with that in the control group (P<0.05).

The application of Modified Simiao Yong'an Decoction combined with acupuncture at sensitized acupoints in the patients with acute coronary syndrome after PCI can effectively improve the related symptoms such as chest tightness and shortness of breath, inhibit the thrombosis, improve the platelet function, reduce the vascular endothelial damage and at the same time inhibit the abnormal expressions of myocardial apoptosis factors, playing a role in improving the prognosis.