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Research Progress on Chemical Composition, Pharmacological Effect and Clinical Application and Quality Marker Prediction Analysis of Yigong San (异功散)
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Yongmei GUAN1, 2, Tingting WANG1, 2, Zhiquan WANG2, 3, Lili XIONG2, 3, Zhenzhen TIAN2, 3, Zhenzhong ZANG1, Weifeng ZHU1, Danfeng WANG2, 3, Yangming WU2, 3
Chinese Archives of Traditional Chinese Medicine | 2026, 44(7) : 13 - 21
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Chinese Archives of Traditional Chinese Medicine | 2026, 44(7): 13-21
• New Opinion of Ph.D. Supervisor •
Research Progress on Chemical Composition, Pharmacological Effect and Clinical Application and Quality Marker Prediction Analysis of Yigong San (异功散)
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Yongmei GUAN1, 2, Tingting WANG1, 2, Zhiquan WANG2, 3, Lili XIONG2, 3, Zhenzhen TIAN2, 3, Zhenzhong ZANG1, Weifeng ZHU1, Danfeng WANG2, 3, Yangming WU2, 3
Affiliations
  • 1.Key Laboratory of Modern Chinese Preparation, Ministry of Education, Jiangxi University of Chinese Medicine, Nanchang 330004, Jiangxi, China
  • 2.National Key Laboratory for the Creation and Preparation of Modern Traditional Chinese Medicine with Classical Formulas, Nanchang 330004, Jiangxi, China
  • 3.China Resources Jiangzhong Pharmaceutical Co., Ltd., Nanchang 330006, Jiangxi, China
Published: 2026-07-10 doi: 10.13193/j.issn.1673-7717.2026.07.003
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Yigong San (异功散) is from Xiaoer Yaozheng Zhijue and is used in treating children with deficiency of Qi in the spleen and stomach, or complicated with Qi stagnation. Modern research has shown that Yigong San has the pharmacological effects of regulating gastrointestinal motility, enhancing immune function, anti-tumor, anti-inflammation and anti-oxidation and regulating intestinal flora. Its clinical applications include pediatric dyspepsia, pediatric diarrhea, bronchial asthma and chronic anemia. This paper systematically summarized the chemical composition, pharmacological effects and clinical application of Yigong San, and predicted its quality markers (Q-Markers) based on the “five principles” of traditional Chinese medicines, among which ginsenosides Rg1, Re, Rb1, atractylenolide Ⅰ, Ⅱ, Ⅲ, pachymic acid, polyporenic acid C, dehydrotumulosic acid, hesperidin, glycyrrhizic acid, glycyrrhetinic acid, liquirtin, 6-gingerol, betulinic acid and other components can be used as the Q-Markers for Yigong San, aiming to provide a good solution for Yigong San.

Yigong San (异功散)  /  chemical composition  /  pharmacological effects  /  clinical application  /  quality markers
管咏梅, 王婷婷, 王智权, 熊丽丽, 田真真, 臧振中, 朱卫丰, 王丹凤, 吴样明. 经典名方异功散化学成分、药理作用、临床应用研究进展及质量标志物预测分析. 中华中医药学刊, 2026 , 44 (7) : 13 -21 . DOI: 10.13193/j.issn.1673-7717.2026.07.003
Yongmei GUAN, Tingting WANG, Zhiquan WANG, Lili XIONG, Zhenzhen TIAN, Zhenzhong ZANG, Weifeng ZHU, Danfeng WANG, Yangming WU. Research Progress on Chemical Composition, Pharmacological Effect and Clinical Application and Quality Marker Prediction Analysis of Yigong San (异功散)[J]. Chinese Archives of Traditional Chinese Medicine, 2026 , 44 (7) : 13 -21 . DOI: 10.13193/j.issn.1673-7717.2026.07.003
Appendix
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Year 2026 volume 44 Issue 7
91
17
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doi: 10.13193/j.issn.1673-7717.2026.07.003
  • Online Date：2026-10-20
  • Published：2026-07-10
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    1.Key Laboratory of Modern Chinese Preparation, Ministry of Education, Jiangxi University of Chinese Medicine, Nanchang 330004, Jiangxi, China
    2.National Key Laboratory for the Creation and Preparation of Modern Traditional Chinese Medicine with Classical Formulas, Nanchang 330004, Jiangxi, China
    3.China Resources Jiangzhong Pharmaceutical Co., Ltd., Nanchang 330006, Jiangxi, China
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表12种不同金属材料的力学参数
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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