To investigate the clinical effect and safety of Dongyuan Qingshu Yiqi Decoction (东垣清暑益气汤) in treating senile asthenia syndrome of spleen deficiency and phlegm-dampness type.

A total of 120 patients with senile asthenic syndrome of spleen deficiency and phlegm-dampness type admitted to the Department of Geriatrics of Qingdao Haici Hospital Affiliated to Qingdao University from January 2022 to November 2024 were divided into two groups by random number table method. The control group (60 cases) received treatment of basic diseases, rehabilitation exercise and nutrition intervention, health education and oral enteral nutrition of whole protein type. The treatment group (60 cases) was combined with Dongyuan Qingshu Yiqi Decoction on the basis of the treatment of the control group. The course of treatment of both groups was 8 weeks. The clinical data of the two groups was compared, including the clinical efficacy, adverse reactions, total scores of TCM symptoms, grip strength, walking speed, Timed Up and Go Test (TUG), five times sit to stand (FTSS), body mass index (BMI) and inflammatory burden index (IBI), immune markers such as CD4+, CD8+, CD4+/CD8+, mini mental state examination (MMSE), Pittsburgh sleep quality index (PSQI), activity of daily living (ADL) score and mini-nutritional assessment (MNA) score.

The effective rate of the observation group was higher than that of the control group (P<0.05). No serious adverse reactions were observed in both groups. After treatment, the total scores of TCM syndromes, Fried asthenic syndrome scale scores, grip strength and walking speed, the results of TUG, FTSS, BMI, IBI, CD4+, CD8+, CD4+/CD8+, MMSE, PSQI, ADL and MNA in the observation group were all better than those in the control group (P<0.05).

The clinical effect of Dongyuan Qingshu Yiqi Decoction on senile asthenia syndrome of spleen deficiency and phlegm-dampness is good, safe and reliable.