Full
Outline
To observe the clinical efficacy of Xiaomudan Granules (消木丹颗粒) combined with polyene phosphatidylcholine capsules in the treatment of non-alcoholic fatty liver disease and its effect on intestinal bacterial colony count.
A total of 106 patients with non-alcoholic fatty liver disease (March 2016 to February 2017) were selected from the hospital and randomly divided into a control group and a treatment group, with 53 patients in each group. The control group took polyene phosphatidylcholine capsules orally, while the treatment group received Xiaomudan Granules in addition to polyene phosphatidylcholine capsules. Both groups were treated for 12 weeks. The changes in clinical symptoms, liver function, blood lipids and gut bacterial colony count were compared between two groups.
The total effective rate of the clinical symptoms in the treatment group was 88.68% (47/53), which was higher than that in the control group [73.58% (39/53), P<0.05]. After treatment, the TCM syndrome scores of both groups decreased compared to those before treatment, and the scores of the treatment group were lower than those of the control group (P<0.05). After treatment, the liver function levels of both groups decreased compared to those before treatment, and the indicator levels of the treatment group were lower than those of the control group (P<0.05). After treatment, the levels of TC, TG, and LDL-C in both groups decreased compared to those before treatment, while the HDL-C level increased. The improvement in the treatment group was better than that in the control group (P<0.05). The improvement of gut microbiota in the treatment group was better than that in the control group (P<0.05).
The combination of Xiaomudan Granules and polyene phosphatidylcholine capsules has significant therapeutic effects in improving clinical symptoms, liver function and blood lipids, and regulating intestinal bacterial colony count in the patients with non-alcoholic fatty liver disease.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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