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Research Progress on Modern Applications and Pharmacological Effects of Guipi Decoction (归脾汤) and Its Quality Marker Predictive Analysis
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Yamin KONG1, 2, Lyuyuan LIANG1, 2, 3, Jialei CAO1, 2, 3, Yifang SHEN1, 2, Shengjia DING1, 2, Fengzhen GUO1, 2, Yujie CHANG1, 2, Yihan LI1, 2, Jingwen LI1, 2, Qing TANG1, 2, Bingqi WEI1, 2, 3, Bingxiang MA1, 2, Wenli SHI4
Chinese Archives of Traditional Chinese Medicine | 2026, 44(8) : 116 - 125
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Chinese Archives of Traditional Chinese Medicine | 2026, 44(8): 116-125
• Target on National Project •
Research Progress on Modern Applications and Pharmacological Effects of Guipi Decoction (归脾汤) and Its Quality Marker Predictive Analysis
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Yamin KONG1, 2, Lyuyuan LIANG1, 2, 3, Jialei CAO1, 2, 3, Yifang SHEN1, 2, Shengjia DING1, 2, Fengzhen GUO1, 2, Yujie CHANG1, 2, Yihan LI1, 2, Jingwen LI1, 2, Qing TANG1, 2, Bingqi WEI1, 2, 3, Bingxiang MA1, 2, Wenli SHI4
Affiliations
  • 1.Hospital of Pediatrics of The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450099, Henan, China
  • 2.School of Pediatrics, Henan University of Chinese Medicine, Zhengzhou 450046, Henan, China
  • 3.Research and Development Center of Classical Prescriptions, Henan Liang Jishi Research Institute of Chinese Medicine, Zhengzhou 450000, Henan, China
  • 4.Xiyuan Hospital, China Academy of Chinese Medical Science, Beijing 100091, China
Published: 2026-08-10 doi: 10.13193/j.issn.1673-7717.2026.08.025
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Guipi Decoction (归脾汤) is a classic formula used throughout history for treating deficiency of both Qi and blood in heart and spleen, as well as spleen failure to control blood. Its modern applications primarily focus on the neuroendocrine system, commonly addressing conditions like insomnia or hypersomnia. This decoction is known to improve immune function, exhibit anti-inflammatory and anti-tumor effects, regulate gastrointestinal function, and enhance psychological well-being. Referring to the five principles of core quality concept of traditional Chinese medicine quality markers (Q-markers) proposed by Academician LIU Changxiao in 2016, the prediction and analysis of Q-markers of Guipi Decoction were carried out, and the Q-markers were finally determined to be astragaloside Ⅳ, calycosin, quercetin, ginsenoside Rg1, ginsenoside Rb1, ginsenoside Re, atractylenolide Ⅰ, atractylolactone Ⅱ, atractylolactone Ⅲ, ferulic acid, ligustilide, pachymic acid, dehydrotumulosic acid, dehydropachymic acid, jujuboside A, costunolide, dehydrocostus, tenuifolin, polygalaxanthone Ⅲ,3,6-disinapyryl sucrose, disinapoylsucrose, betulinic acid, oleanolic acid, liquiritin and glycyrrhizic acid.

Guipi Decoction (归脾汤)  /  classic prescriptions  /  modern applications  /  quality markers  /  pharmacological effect
孔亚敏, 梁绿圆, 曹佳蕾, 沈艺芳, 丁圣家, 郭凤真, 常雨洁, 李懿涵, 李静雯, 唐箐, 魏炳琦, 马丙祥, 史文丽. 经典名方归脾汤现代应用和药理作用研究进展及其质量标志物预测分析. 中华中医药学刊, 2026 , 44 (8) : 116 -125 . DOI: 10.13193/j.issn.1673-7717.2026.08.025
Yamin KONG, Lyuyuan LIANG, Jialei CAO, Yifang SHEN, Shengjia DING, Fengzhen GUO, Yujie CHANG, Yihan LI, Jingwen LI, Qing TANG, Bingqi WEI, Bingxiang MA, Wenli SHI. Research Progress on Modern Applications and Pharmacological Effects of Guipi Decoction (归脾汤) and Its Quality Marker Predictive Analysis[J]. Chinese Archives of Traditional Chinese Medicine, 2026 , 44 (8) : 116 -125 . DOI: 10.13193/j.issn.1673-7717.2026.08.025
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Year 2026 volume 44 Issue 8
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doi: 10.13193/j.issn.1673-7717.2026.08.025
  • Online Date：2026-10-20
  • Published：2026-08-10
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Affiliations
    1.Hospital of Pediatrics of The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450099, Henan, China
    2.School of Pediatrics, Henan University of Chinese Medicine, Zhengzhou 450046, Henan, China
    3.Research and Development Center of Classical Prescriptions, Henan Liang Jishi Research Institute of Chinese Medicine, Zhengzhou 450000, Henan, China
    4.Xiyuan Hospital, China Academy of Chinese Medical Science, Beijing 100091, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
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Genus		 种数
Number of
species		 占总种数比例
Percentage of total
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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