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Catalpol and Rehmannioside A from Shengdiihuang (Rehmanniae Radix) Activate Autophagy And Inhibit Apoptosis In Pancreatic β-Cells To exert anti-T2DM Effects
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Nan HU1, Xianglong MENG1, 2, 3, 4, Hongchang LI2, Shuosheng ZHANG1, 2, 3, 4
Chinese Archives of Traditional Chinese Medicine | 2026, 44(8) : 111 - 115
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Chinese Archives of Traditional Chinese Medicine | 2026, 44(8): 111-115
• Target on National Project •
Catalpol and Rehmannioside A from Shengdiihuang (Rehmanniae Radix) Activate Autophagy And Inhibit Apoptosis In Pancreatic β-Cells To exert anti-T2DM Effects
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Nan HU1, Xianglong MENG1, 2, 3, 4, Hongchang LI2, Shuosheng ZHANG1, 2, 3, 4
Affiliations
  • 1.Traditional Chinese Medicine and Food Engineering, Shanxi University of Chinese Medicine, Jinzhong 030619, Shanxi, China
  • 2.Shanxi Key Laboratory of Chinese Herbal Medicine Processing, Shanxi University of Chinese Medicine, Jinzhong 030619, Shanxi, China
  • 3.Key Research Laboratory of Processing and Innovation in Traditional Chinese Medicinal Materials, Shanxi University of Chinese Medicine, Jinzhong 030619, Shanxi, China
  • 4.Traditional Chinese Medicine Processing Technology Inheritance Base (Shanxi University of Chinese Medicine), Jinzhong 030619, Shanxi, China
Published: 2026-08-10 doi: 10.13193/j.issn.1673-7717.2026.08.024
Outline
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Objective

Explored the protective effects of two iridoid compounds, catalpol and rehmannioside A (ReA), from the traditional Chinese medicine Shengdiihuang (Rehmanniae Radix), against hydrogen peroxide (H2O2)-induced injury of pancreatic β-cells in vitro, as well as their molecular mechanisms in the treatment of type 2 diabetes mellitus (T2DM).

Methods

By utilizing an H2O2-induced injury model of rat insulinoma cells (INS-1) and mouse pancreatic β-cells (MIN6), the effects of catalpol and ReA on cell viability and proliferation were evaluated. Additionally, flow cytometry, cellular immunofluorescence and protein immunoblotting were employed to detect autophagy, apoptosis and the expressions of related proteins.

Results

Catalpol and ReA can significantly increase the survival rate of H2O2-induced INS-1 and MIN6 cells (P<0.01), markedly enhance the cell proliferation vitality (P<0.01), effectively reduce the apoptosis rate of cells (P<0.01), significantly increase the relative fluorescence intensity of Microtubule-associated protein light chain 3 (LC3) protein in cells (P<0.01), up-regulate the expressions of Beclin 1, LC3B Ⅱ, Autophagy related 7 (ATG7), Autophagy related 5 (ATG5), B-cell lymphoma-2 (Bcl-2), Cysteinyl aspartate specific proteinase-9 (Caspase-9), Cysteinyl aspartate specific proteinase-3 (Caspase-3), Poly ADP-ribose polymerase 1 (PARP1) proteins in cells (P<0.05, P<0.01) and down-regulate the expressions of Sequestosome 1 (P62) and Bcl-2 associated X protein (Bax) proteins in cells (P<0.05, P<0.01).

Conclusion

Catalpol and ReA exert their anti-T2DM effects by enhancing autophagic activity, reducing cell apoptosis caused by oxidative damage, and improving the viability and proliferation of pancreatic β-cells.

catalpol  /  rehmannioside A  /  pancreatic β-cells  /  autophagy  /  apoptosis
胡楠, 孟祥龙, 李鸿昌, 张朔生. 生地黄中梓醇和地黄苷A通过激活胰岛β细胞自噬抑制凋亡发挥抗2型糖尿病作用. 中华中医药学刊, 2026 , 44 (8) : 111 -115 . DOI: 10.13193/j.issn.1673-7717.2026.08.024
Nan HU, Xianglong MENG, Hongchang LI, Shuosheng ZHANG. Catalpol and Rehmannioside A from Shengdiihuang (Rehmanniae Radix) Activate Autophagy And Inhibit Apoptosis In Pancreatic β-Cells To exert anti-T2DM Effects[J]. Chinese Archives of Traditional Chinese Medicine, 2026 , 44 (8) : 111 -115 . DOI: 10.13193/j.issn.1673-7717.2026.08.024
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doi: 10.13193/j.issn.1673-7717.2026.08.024
  • Online Date：2026-10-20
  • Published：2026-08-10
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Affiliations
    1.Traditional Chinese Medicine and Food Engineering, Shanxi University of Chinese Medicine, Jinzhong 030619, Shanxi, China
    2.Shanxi Key Laboratory of Chinese Herbal Medicine Processing, Shanxi University of Chinese Medicine, Jinzhong 030619, Shanxi, China
    3.Key Research Laboratory of Processing and Innovation in Traditional Chinese Medicinal Materials, Shanxi University of Chinese Medicine, Jinzhong 030619, Shanxi, China
    4.Traditional Chinese Medicine Processing Technology Inheritance Base (Shanxi University of Chinese Medicine), Jinzhong 030619, Shanxi, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
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Genus		 种数
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Percentage of total
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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