To explore the effects of Aescuven forte in the treatment of acute traumatic knee synovitis and influence on serum levels of osteoprotegerin (OPG), transforming growth factor-β1 (TGF-β1) and interleukin 6 (IL-6).

A total of 100 patients with acute traumatic knee synovitis induced were selected and divided into the control group (50 cases) and the observation group (50 cases) by random number table method. The control group received routine treatment, and the observation group received oral treatment with Aescuven forte on the basis of the control group, the course of treatment was 14 days. Visual analogue scale (VAS) score, Western Ontario and McMaster Universities osteoarthritis index (WOMAC) score, knee Lysholm score, synovial thickness, effusion depth, depth of fluid accumulation and difference of knee diameter, and the levels of serum OPG, TGF-β1 and IL-6 were compared.

There was no significant difference in VAS score, WOMAC score, Lysholm score, synovial thickness, effusion depth or peri-diameter difference of knee joint between the observation group and the control group (P>0.05). After treatment, VAS scores, WOMAC scores, synovial thickness, effusion depth and peri-diameter difference of knee joint decreased compared with those before treatment (P<0.05). The results of the observation group were lower than those of the control group (P<0.05). The Lysholm scores in two groups were higher than those before treatment (P<0.05), and the score of the observation group was higher than that of the control group (P<0.05). There was no statistically significant difference in the levels of serum OPG, TGF-β1 or IL-6 between the two groups before treatment (P>0.05). The levels of serum OPG and TGF-β1 elevated after treatment compared with those before treatment (P<0.05). The serum IL-6 levels decreased after treatment compared with those before treatment (P<0.05) and the level of the observation group was lower than that of the control group (P<0.05). The therapeutic effect of the observation group was better than that of the control group (P<0.05). The incidence of adverse reactions in the control group and the observation group was 14.00% and 18.00%, respectively, with no statistical significance (P>0.05).

Aescuven forte in the treatment of acute traumatic knee synovitis can improve the therapeutic effect, the levels of OPG, TGF-β1 and IL-6. Its effect may be related to improving knee bone metabolism, promoting wound repair and alleviating inflammatory response.