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Exploring How Iron Deficiency Anemia Promotes Development of Various Cardiovascular Diseases Based on Concept of “Insufficient Blood Nourishing Heart”
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Chengjia LI1, Yabin ZHOU1, Qi YUAN2, Tianwei MENG1, Changxing LIU1, Nan JIANG3, Boyu WNAG1, Jiarui LI1, Zhiping LIU4, 5, Huijun CHEN4
Chinese Archives of Traditional Chinese Medicine | 2026, 44(1) : 140 - 145
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Chinese Archives of Traditional Chinese Medicine | 2026, 44(1): 140-145
• Target on National Project •
Exploring How Iron Deficiency Anemia Promotes Development of Various Cardiovascular Diseases Based on Concept of “Insufficient Blood Nourishing Heart”
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Chengjia LI1, Yabin ZHOU1, Qi YUAN2, Tianwei MENG1, Changxing LIU1, Nan JIANG3, Boyu WNAG1, Jiarui LI1, Zhiping LIU4, 5, Huijun CHEN4
Affiliations
  • 1.Heilongjiang University of Chinese Medicine, Harbin 150040, Heilongjiang, China
  • 2.Mudanjiang Medical University, Mudanjiang 157011, Heilongjiang, China
  • 3.Second People’s Hospital of Zhoushan, Zhoushan 316000, Zhejiang, China
  • 4.Second Affiliated Hospital to Heilongjiang University of Chinese Medicine, Harbin 150001, Heilongjiang, China
  • 5.The First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin 150040, Heilongjiang, China
Published: 2026-01-10 doi: 10.13193/j.issn.1673-7717.2026.01.029
Outline
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Objective

By validating the association between iron deficiency anemia（IDA）and various cardiovascular diseases，it can deepen and expand the understanding of the traditional Chinese medicine concept that insufficient blood leads to heart issues，which in turn causes pain.

Methods

Large-scale genome-wide association study（GWAS）data on unstable angina（UA），stable angina（SA），heart failure（HF），ischemic heart disease（IHD），atrial fibrillation（AF）and myocardial infarction（MI）were obtained from the Open gwas website. The strongly correlated single nucleotide polymorphisms（SNP）in GWAS were selected as instrumental variables（P<5e-06），and the threshold of F statistics was set to 10. A total of five statistical methods were used to analyze the results，with the inverse variance weighted（IVW）method as the main analysis method. And the reliability of the results for heterogeneity，pleiotropy and sensitivity was assessed.

Results

IDA had a promoting effect on the incidence of UA，SA，HF and IHD（UA：OR，1.25，95% CI［1.10，1.40］，P=0.000 3；SA：OR，1.14，95% CI［1.04，1.26］，P=0.006；HF：OR，1.13，95% CI［1.02，1.25］，P=0.018 7；IHD：OR，1.13，95% CI［1.02，1.25］，P=0.023 8）. IDA was not found to have a significant promoting effect on AF or MI（P>0.05）. The results passed the tests of heterogeneity，pleiotropy and sensitivity.

Conclusions

IDA can increase the risk of UA，SA，HF and IHD. There is no evidence to support that IDA can increase the risk of MI and AF.

iron deficiency anemia  /  cardiovascular diseases  /  gene  /  Mendelian randomization
李呈佳, 周亚滨, 袁琦, 孟天伟, 刘长兴, 姜楠, 王博宇, 李佳睿, 刘志平, 陈会君. 基于“血不荣心”探讨缺铁性贫血促进多种心血管疾病的发展. 中华中医药学刊, 2026 , 44 (1) : 140 -145 . DOI: 10.13193/j.issn.1673-7717.2026.01.029
Chengjia LI, Yabin ZHOU, Qi YUAN, Tianwei MENG, Changxing LIU, Nan JIANG, Boyu WNAG, Jiarui LI, Zhiping LIU, Huijun CHEN. Exploring How Iron Deficiency Anemia Promotes Development of Various Cardiovascular Diseases Based on Concept of “Insufficient Blood Nourishing Heart”[J]. Chinese Archives of Traditional Chinese Medicine, 2026 , 44 (1) : 140 -145 . DOI: 10.13193/j.issn.1673-7717.2026.01.029
Appendix
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Year 2026 volume 44 Issue 1
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Article Info
doi: 10.13193/j.issn.1673-7717.2026.01.029
  • Online Date：2026-10-14
  • Published：2026-01-10
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Affiliations
    1.Heilongjiang University of Chinese Medicine, Harbin 150040, Heilongjiang, China
    2.Mudanjiang Medical University, Mudanjiang 157011, Heilongjiang, China
    3.Second People’s Hospital of Zhoushan, Zhoushan 316000, Zhejiang, China
    4.Second Affiliated Hospital to Heilongjiang University of Chinese Medicine, Harbin 150001, Heilongjiang, China
    5.The First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin 150040, Heilongjiang, China
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https://castjournals.cast.org.cn/joweb/zhzyyxk/EN/10.13193/j.issn.1673-7717.2026.01.029
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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