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Research Progress of Qing'e Pill（青娥丸）in Regulating Bone Metabolism to Treat Osteoporosis
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Xilan MA1, 2, Lifu YUAN2, Xiaonan QI3, Jiaxuan ZHAO2, Zhong CHAI2, Jian ZHANG2, Xu LIANG2, Shixuan WANG2
Chinese Archives of Traditional Chinese Medicine | 2026, 44(2) : 80 - 84
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Chinese Archives of Traditional Chinese Medicine | 2026, 44(2): 80-84
• Target on National Project •
Research Progress of Qing'e Pill（青娥丸）in Regulating Bone Metabolism to Treat Osteoporosis
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Xilan MA1, 2, Lifu YUAN2, Xiaonan QI3, Jiaxuan ZHAO2, Zhong CHAI2, Jian ZHANG2, Xu LIANG2, Shixuan WANG2
Affiliations
  • 1.Liaoning University of Traditional Chinese Medicine，Shenyang 110847，Liaoning，China
  • 2.Liaoning Academy of Traditional Chinese Medicine，The Second Affiliated Hospital of Liaoning University of Traditional Chinese Medicine，Shenyang 110034，Liaoning，China
  • 3.The Affiliated Hospital of Liaoning University of Traditional Chinese Medicine，Shenyang 110032，Liaoning，China
Published: 2026-02-10 doi: 10.13193/j.issn.1673-7717.2026.02.015
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Osteoporosis（OP）has complex etiology and its incidence is on the rise. Delayed treatment will increase the risk of fractures and other complications. Qing'e Pill（青娥丸）is an effective prescription for treating kidney-deficiency low back pain. Its formulation has few ingredients but specific effects，with the functions of warming and tonifying kidney Yang，securing the essence and nourishing blood，tonifying liver and kidney，and strengthening muscles and bones. Modern pharmacological studies have shown that Duzhong（Eucommiae Cortex），Buguzhi（Psoraleae Fructus），Hetaoren（Juglandis Semen）and Dasuan（Allii Sativi Bulbus）in the prescription all have the effect of treating OP. As a traditional Chinese medicine compound，Qing'e Pill has the characteristics of “multi-component and multi-target”. For the treatment of OP，it can exert the estrogen-like effects，promote the bone formation，inhibit the bone resorption，affect the intestinal flora and inhibit the ferroptosis. Clinical studies have shown that Qing’e Pill can improve the clinical symptoms of OP. This article elaborated on the regulatory effect and research status of Qing’e Pill on bone metabolism in OP research from the aspects of the pharmacological mechanism of each ingredient of Qing’e Pill，the overall pharmacological mechanism and clinical research，in order to provide reference for the research and development of anti-osteoporosis drugs and the scientific understanding，inheritance and development of traditional Chinese medicine.

Qing’e Pill（青娥丸）  /  osteoporosis  /  bone metabolism  /  mechanism of action
马熙蘭, 袁立夫, 戚晓楠, 赵佳萱, 柴忠, 张健, 梁旭, 王世轩. 青娥丸调控骨代谢治疗骨质疏松的研究进展. 中华中医药学刊, 2026 , 44 (2) : 80 -84 . DOI: 10.13193/j.issn.1673-7717.2026.02.015
Xilan MA, Lifu YUAN, Xiaonan QI, Jiaxuan ZHAO, Zhong CHAI, Jian ZHANG, Xu LIANG, Shixuan WANG. Research Progress of Qing'e Pill（青娥丸）in Regulating Bone Metabolism to Treat Osteoporosis[J]. Chinese Archives of Traditional Chinese Medicine, 2026 , 44 (2) : 80 -84 . DOI: 10.13193/j.issn.1673-7717.2026.02.015
Appendix
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Year 2026 volume 44 Issue 2
94
12
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doi: 10.13193/j.issn.1673-7717.2026.02.015
  • Online Date：2026-10-14
  • Published：2026-02-10
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Affiliations
    1.Liaoning University of Traditional Chinese Medicine，Shenyang 110847，Liaoning，China
    2.Liaoning Academy of Traditional Chinese Medicine，The Second Affiliated Hospital of Liaoning University of Traditional Chinese Medicine，Shenyang 110034，Liaoning，China
    3.The Affiliated Hospital of Liaoning University of Traditional Chinese Medicine，Shenyang 110032，Liaoning，China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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