Full
Outline
Dahuang（Rhei Radix et Rhizoma）is one of the traditional bulk medicinal materials in China. It has a long history and wide application in the treatment of constipation because of its efficacy of purging，clearing heat and purging fire，cooling blood and detoxifying，removing blood stasis and dredging meridians，and removing dampness and jaundice. Constipation is one of the most common functional gastrointestinal diseases. The incidence of constipation is increasing year by year，seriously endangering the health of the body. At present，although the chemical drugs can achieve remarkable results in the short term，the long-term use often has the problems of gradually weakened efficacy and adverse reactions. Modern pharmacological studies have shown that Dahuang（Rhei Radix et Rhizoma）can regulate intestinal flora and metabolites，intestinal mucus secretion，as well as the expressions of ion channels，aquaporins，neurotransmitters，etc.，and promote the intestinal motility. Dahuang（Rhei Radix et Rhizoma）can play a role in the treatment and protection of constipation through different processing methods，administration routes and combined medication，multi-target，multi-channel and multi-channel. This article reviewed the research progress of Dahuang（Rhei Radix et Rhizoma）in the treatment of constipation from the aspects of processing，optimal efficacy，clinical application，pharmacological effects and toxicology，in order to provide some reference value for the further research and application of Dahuang（Rhei Radix et Rhizoma）and the development of drugs related to the treatment of constipation.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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