Full
Outline
Mitophagy acts as a crucial mediator in the progression of heart failure（HF）after myocardial infarction（MI），characterized by the clearance of the damaged mitochondria and the maintenance of mitochondrial homeostasis. The regulation of mitophagy exerts a protective effect on cardiomyocytes post-MI. The theory of “harmful hyperactivity and responding inhibition” in traditional Chinese medicine elucidates the physiological and pathological phenomena in the human body and guides the clinical practice. The pathological mechanism underlying mitophagy dysfunction in HF after MI aligns with the theoretical essence that “hyperactivity is harmful，and commitment is a control.” The involvement of the internal organs results in the impaired Qi transformation，leading to the failure of the dispersal of essence，blood and body fluids，as well as the obstruction of phlegm，water and stagnant toxins within the heart vessels. This presents an excess of harm，manifested by the accumulation of inflammatory factors and reactive oxygen species（ROS），which contributes to the aggravation of mitophagy dysfunction. The interaction between these two aspects creates a vicious cycle that is pivotal to the progression from MI to HF. Adhering to the treatment principle of “restraining excess and alleviating hyperactivity”，and applying traditional Chinese medicine interventions that respect the pathogenesis characteristics can inhibit the mitochondrial damage，regulate the mitophagy，promote the clearance of inflammatory factors and ROS，protect the cardiomyocytes，and improve the cardiac function.
102
18
| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
关闭全屏
No. 86 Xueyuan South Road, Haidian District, Beijing
010-62662699(Operation and Technical Support)
qkjq@cast.org.cn
Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House
