To study the effect of Longsha opening and closing pivot needle method combined with letrozole（LE）and human chorionic gonadotropin（HCG）on infertility in polycystic ovary syndrome（PCOS）.

From June 2021 to October 2022, 84 patients with PCOS admitted to Wuxi Hospital of Traditional Chinese Medicine were divided into the control group（42 cases）and the acupuncture group（42 cases）by random number table method. The control group was treated with LE and HCG, and the acupuncture group was treated with Longsha opening and closing pivot needle method for 6 menstrual cycles. Endometrial indexes, sex hormones and metabolic indexes before and after 6 menstrual cycles of treatment, therapeutic effect after 6 menstrual cycles, adverse reactions and pregnancy during treatment were compared between the two groups.

Compared with those before treatment and after 6 menstrual cycles, the levels of endometrial thickness（ET）and the proportion of endometrial type A and the level of serum estradiol（E2）increased in both groups, and the overall ratio was higher in the acupuncture group（P < 0.05）. Compared with those before treatment and after 6 menstrual cycles, the pulsing index（PI）and resistance index（RI）, the levels of testosterone（T）, luteinizing hormone（LH）, follicle stimulating hormone（FSH）, fasting blood glucose（FPG）, insulin（INS）, insulin resistance index（HOMA-IR）, triglyceride（TG）and total cholesterol（TC）of the two groups decreased, and were lower than those of the acupuncture group（P < 0.05）. After 6 menstrual cycles, the clinical effect of the acupuncture group was better than that of the control group（P < 0.05）. During the treatment period, no significant adverse reactions occurred in the two groups, and the incidence of adverse reactions between the two groups was 14.29%（6/42）vs 9.52%（4/42）, with no statistical significance（P > 0.05）. The incidence of biochemical pregnancy rate and clinical pregnancy rate were higher in the acupuncture group（P < 0.05）.

Longsha opening and closing pivot needle method combined with LE and HCG in the treatment of PCOS infertility could improve the endometrial indexes, regulate the sex hormones and metabolic indexes, and finally improve the pregnancy, with accurate efficacy and good safety.