To study the curative effect of Zengye Decoction（增液汤）on functional constipation in children with dyspepsia and food accumulation transforming into heat type and its effect on serum gastrin（GAS）, motilin（MLT）and gastrointestinal hormone substance P（SP）.

From November 2023 to May 2024, 98 children with functional constipation of food accumulation and heat type treated in the hospital were selected and divided into two groups according to the random number table method, with 49 children in each group. The control group was treated with lactulose oral liquid and bacillus subtilis and enterococcus faecium granules. The observation group was treated with Zengye Decoction. Two weeks was a course of treatment. The curative effect, TCM syndrome scores, disappearance time of TCM syndrome, changes of serum GAS, MLT and SP and adverse reactions were compared between the two groups.

The clinical cure rate of the observation group was 69.39%, which was significantly higher than that of the control group（46.94%）（P < 0.05）. After treatment, the scores of defecation interval, dry stool, difficult defecation and fecal incontinence in the two groups were significantly decreased, the scores of the defecation interval, dry stool and difficult defecation in the observation group were significantly lower than those in the control group（P < 0.05）. The time of defecation interval prolongation, dry stool, difficult defecation and disappearance of fecal incontinence in the observation group were significantly shorter than those in the control group（P < 0.05）. After treatment, the levels of serum GAS and SP in the two groups were significantly increased, and the level of MLT in the observation group was also significantly increased, but there was no significant change in the level of MLT in the control group, After treatment, the levels of serum GAS, MLT and SP in the observation group were significantly higher than those in the control group（P < 0.05）. The incidence of adverse reactions was 6.12% in the observation group and 10.20% in the control group. There was no significant difference between the two groups（P > 0.05）.

The curative effect of Zengye Decoction in the treatment of functional constipation in children with food accumulation transforming into heat type is satisfactory. It can improve the clinical cure rate and relieve the symptoms, and promote the rehabilitation of children by effectively regulating their gastrointestinal hormone levels, so it has safe and reliable application value.