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Jiangzhizi（Gardeniae Fructus）is the dry and mature fruit of Zhizi（Gardenia jasminoides Ellis）. It is a famous authentic medicinal herb with diverse chemical components, mainly including iridoids, monoterpenoid glycoside, diterpenoids, triterpenoids, organic ester, flavone and volatile oil. In this study, 600 targets of Jiangzhizi（Gardeniae Fructus）were obtained based on the prediction of chemical structure similarity, and the top 20 highly related diseases of Jiangzhizi（Gardeniae Fructus）were obtained through disease enrichment analysis. The disease classification obtained from the enrichment was mapped to the traditional Chinese medicine diseases treated with Jiangzhizi（Gardeniae Fructus）, and the network topology model was used to analyze and predict the corresponding quality markers（Q-Markers）of different traditional Chinese medicine diseases treated with Jiangzhizi（Gardeniae Fructus）. The results showed that geniposide, crocin-1, barbinervic acid, rotundic acid, methyl linoleate and crocusatin-C were the candidate Q-Markers for the treatment of fever and restlessness with Jiangzhizi（Gardeniae Fructus）. Barbinervic acid, rotundic acid, methyl linoleate, geniposide, hederagenin, clethric acid, myrianthic acid, pentyl hexanoate, quercetin and crocin-1 were the candidate Q-Markers for the treatment of damp-heat jaundice with Jiangzhizi（Gardeniae Fructus）. Geniposide, barbinervic acid, rotundic acid, pentyl hexanoate, methyl linoleate, quercetin and crocin-1 were the candidate Q-Markers for the treatment of stranguria with astringent pain and hematemesis due to blood heat with Jiangzhizi（Gardeniae Fructus）.While quercetin, methyl linoleate and geniposide were the candidate Q-Markers for the treatment of fire sores and sprains contusions pain with Jiangzhizi（Gardeniae Fructus）. The significance of this study is to provide a theoretical basis for the precise quality control and in-depth development of Jiangzhizi（Gardeniae Fructus）.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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