To observe the effects of Yiqi Huoxue Tiaomai Decoction（益气活血调脉汤）combined with amiodarone on rapid ventricular rate control and cardiac function in patients with atrial fibrillation.

Sixty patients with atrial fibrillation and rapid ventricular rate admitted to the Traditional Chinese Medicine Department of the hospital from January to December 2023 were selected. The patients were randomly divided into two groups using a digitalization method：a control group（taking amiodarone hydrochloride tablets orally, 30 cases）and an observation group（taking Yiqi Huoxue Tiaomai Decoction combined with amiodarone hydrochloride tablets orally, 30 cases）. The clinical efficacy, ventricular rate, heart function, and adverse reactions were compared between two groups.

The effective rate of the control group（73.33%）was significantly lower than that of the observation group（93.33%）, and the difference was statistically significant（P < 0.05）. There was no significant difference in ventricular rate between the two groups before and one week after intervention（P > 0.05）. After 2 weeks of intervention, the ventricular rate of the observation group decreased compared to that of the control group, but the difference was not statistically significant（P > 0.05）. After 3 and 4 weeks of intervention, the ventricular rate of the observation group patients was significantly reduced compared to that of the control group（P < 0.01）. There was no significant difference in the levels of various cardiac function indicators between the two groups before intervention（P > 0.05）. After 4 weeks of intervention, the levels of left ventricular ejection fraction（LVEF）and the ratio of peak early diastolic blood flow to peak late diastolic blood flow in the left ventricle（E/A）of the observation group were significantly increased compared to those of the control group, while the levels of left ventricular end diastolic diameter（LVEDD）and left ventricular end systolic diameter（LVESD）were significantly reduced（P < 0.01）. There was no significant difference in serum levels of angiotensin Ⅱ（Ang-Ⅱ）, norepinephrine（NE）or brain natriuretic peptide（BNP）between the two groups before intervention（P > 0.05）. After 4 weeks of intervention, the serum levels of Ang-Ⅱ, NE and BNP in the observation group were significantly lower than those in the control group（P < 0.01）. There was no significant difference in the scores of main symptoms such as palpitations, chest tightness, heart pain, shortness of breath or fatigue between the two groups before intervention（P > 0.05）. After 4 weeks of intervention, the scores of the above symptoms in the observation group were significantly lower than those in the control group（P < 0.01）. During the intervention period, the two groups experienced adverse reactions, mainly including gastrointestinal discomfort, abnormal liver and kidney function, abnormal bleeding and bradycardia, but there was no significant difference in the overall incidence rate（P > 0.05）.

The combination of Yiqi Huoxue Tiaomai Decoction and amiodarone in the treatment of patients with atrial fibrillation and rapid ventricular rate can not only control the heart rate, but also improve the cardiac function, alleviate the clinical symptoms such as palpitations, chest tightness, pain, shortness of breath and fatigue.