To study the clinical study of Biejiajian Pills（鳖甲煎丸）treating hepatitis B liver fibrosis（blood stasis in liver and spleen syndrome）.

A total of 102 patients with hepatitis B liver fibrosis（blood stasis in liver and spleen syndrome）admitted to the hospital from November 2022 to July 2024 were selected as the study objects and the patients were divided into two groups by random number table method. Fifty-one patients receiving conventional Western medicine were established as the control group and fifty-one patients receiving Biejiajian Pills on the basis of the conventional Western medicine were established as the experimental group. After treatment, the clinical effects of the two groups were observed and compared, including TCMsyndrome scores, hepatitis B virus e antigen（HBeAg）negative conversion rate, hepatitis B virus e antibody（HBe-Ab）positive conversion rate, liver function, liver fiber and inflammatory indicators before and after treatment.

After treatment, the TCMsyndrome scores of both groups decreased, and the scores of the experimental group decreased more significantly than that of the control group（P<0.05）. Compared with those in the control group, the levels of glutalanine transferase（ALT）, glutamic oxalate transferase（AST）and total bilirubin（TBIL）in the experimental group were lower, and the proportion of white ball（A/G）was higher（P<0.05）. Compared with those in the control group, the levels of laminin（LN）, hyaluronic acid（HA）, type Ⅲ procollagen（PC-Ⅲ）and type Ⅳ collagen（C-Ⅳ）in the experimental group were lower（P<0.05）. The conversion rate of HBeAg to negative was 49.02%（25/51）, and the conversion rate of HBeAb to positive was 41.18%（21/51）in the experimental group, which were higher than 27.45%（14/51）and 19.61%（10/51）in the control group（P<0.05）. Compared with those in the control group, the levels of interleukin-15（IL-15）, interleukin-16（IL-16）and transforming growth factor-β1（TGF-β1）in the experimental group were lower（P<0.05）.

Biejiajian Pills can effectively improve the liver function and liver fiber index, reduce the clinical symptoms and control the condition of patients with hepatitis B liver fibrosis（blood stasis in liver and spleen syndrome）, and has high clinical application value.