To study the effect of benefiting Qi and elevating Zong method in the treatment of heart failure with preserved ejection fraction（HFpEF）.

From December 2019 to May 2021, 60 patients with HFpEF treated in Chongqing Hospital of Traditional Chinese Medicine were selected as the research objects. They were divided into two groups by random number grouping method, 30 patients in the control group and 30 patients in the observation group. The patients in the control group were treated with standardized heart failure drugs, and those in the observation group were treated with Yiqi Shengzong Decoction（益气升宗汤）on the basis of the control group. After 4 weeks of treatment, the syndrome efficacy, cardiac structure and cardiac function indexes, vascular inflammation indexes, quality of life and incidence of adverse reactions were compared between the two groups.

The curative effect of the observation group was better than that of the control group, and the total effective rate was 96.67%（29/30）vs 73.33%（22/30）（P<0.05）. The left atrial volume index（LAVI）, left ventricular mass index（LVMI）, early diastolic mitral flow velocity/early diastolic mitral annular velocity（E/e＇）and tricuspid regurgitation peak velocity（TRV）were significantly decreased in the two groups. Compared with those of the control group, the values of each index in the observation group were lower（P<0.05）. After treatment, the 6-minute walking test（6MWT）distance of the two groups increased, and the 6MWT of the observation group was longer than that of the control group（P<0.05）. After treatment, the levels of serum C-reactive protein（CRP）and soluble growth stimulation expressed gene 2（sST2）in the two groups were significantly decreased, and those in the observation group were significantly lower than those of the control group（P<0.05）. After treatment, the scores of Minnesota Heart Failure Quality of Life Scale（MLHFQ）in the two groups were significantly decreased, and those in the observation group were significantly lower than the control group（P<0.05）. No serious adverse reactions occurred in both groups.

The treatment of HFpEF with benefiting Qi and elevating Zong method is satisfactory, and the curative effect of syndrome and NYHA cardiac function is better. It can significantly improve the cardiac structure and cardiac function index, vascular inflammation index and the quality of life. It is an effective and safe medication regimen and is worthy of application.