Full
Outline
To explore the curative effect of Xiaochaihu Jiangni Decoction（小柴胡降逆汤）assisted by esomeprazole in the treatment of gastroesophageal reflux disease（GERD）.
A total of 70 patients with GERD in the hospital from March 2020 to February 2022 were selected as the research objects, and they were randomly divided into two groups, with 35 cases in each group. Both groups were given the standard treatment plan of esomeprazole. After the treatment, the control group continued to intervene without drugs, and the observation group continued to be treated with Xiaochaihu Jiangni Decoction. The clinical efficacy, clinical symptom score before and after treatment, 24 h pH value of esophagus during the 6 months follow-up, and the serum levels of Leptin and interleukin-8（IL-8）of the two groups were statistically compared. And the recurrence during follow-up was compared.
The total effective rate of the observation group was 91.43%（32/35）higher than that of control group 65.71%（23/35）（P<0.05）. The scores of the clinical symptoms（heartburn, belching, acid reflux, retrosternal pain）of the observation group after treatment were lower than those of the control group, 24 h pH value of esophagus during the 6 months follow-up（24 h regurgitation times, regurgitation times >5 min, the longest regurgitation time and the total time percentage of pH <4）, the serum levels of Leptin and interleukin-8（IL-8）were lower than those of the control group（P<0.05）. There was no significant difference in the recurrence rate between the two groups（P>0.05）.
After esomeprazole treatment, the continuous maintenance treatment of Xiaochaihu Jiangni Decoction can effectively relieve symptoms, regulate the serum levels of Leptin and IL-8 and reduce 24 h pH value of esophagus of the patients with GERD, with significant effects and positive significance in preventing recurrence.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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