This study aimed to explore the clinical efficacy of Huanglian Wendan Decoction（黄连温胆汤）combined with acupoint application in the treatment of patients with dampness-heat of spleen and stomach type of functional dyspepsia（FD）and its impacton patients'quality of life and psychological well-being.

This study selected patients diagnosed as dampness-heat of spleen and stomach type of functional dyspepsia（FD）and treated at the hospital from October2021 to October 2023 as the research subjects，totaling 116 cases.According to the random number table method，they were divided into a control group（53 cases）and an experimental group（53 cases）.The patients in the control group received oral treatment with Mosapride Citrate Tablets，while those in the experimental group were treated with Huanglian Wendan Decoction combined with acupoint application on the basis of Mosapride Citrate Tablets.The efficacy of treatments and traditional Chinese medicine（TCM）syndrome scores were assessed and compared between the two groups.The levels of serum motilin（MTL），gastrin（GAS）and ghrelin before and after treatment were statistically compared.The Beck Depression Inventory（BDI），Beck Anxiety Inventory（BAI），Nipine Digestive Dysplasia Life Index Scale（NDLQL）and Medical Outcomes Study Health Survey Short Form-36 Item（SF-36）were used to evaluate the patients'quality of life and psychological state.Adverse reactions to the treatments in both groups were also recorded.

After treatment，the NDSI scores and TCM syndrome scores for primary and secondary symptoms in the experimental group were lower than those in the control group.Post-treatment levels of MTL and GAS decreased while ghrelin levels increased in both groups，with the experimental group showing lower levels ofMTL and GASand higher levels of ghrelin compared to the control group.The SF-36 scores for physical functioning（PF），role-physical（RP），bodily pain（BP），vitality（VT）and social functioning（SF）increased after treatment in both groups，with higher increases observed in the experimental group.The BDIand BAIscores decreased in both groups post-treatment，with the experimental group showing lower scores than the control group.The scores in all four domains of the NDLQI and the total scores increased after treatment in both groups，with the experimental group showing higher scores than the control group（P<0.05）.Compared to the control group，the experimental group had a significantly higher number of safety cases（P<0.05）.

Huanglian Wendan Decoction combined with acupoint application is an effective treatment for dampness-heat of spleen and stomach type of FD，and its further clinical application is warranted.