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Effect of Jujuboside B on Voltage-Gated Sodium Channels in Rat Ventricular Myocytes
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Xiaona DONG1, 2, Jie XIANG3, 4, Ye ZHU2, Shengzhan PENG3, Zhengxin XU3, 4, 5, Xiang GU2
Chinese Archives of Traditional Chinese Medicine | 2025, 43(12) : 55 - 59
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Chinese Archives of Traditional Chinese Medicine | 2025, 43(12): 55-59
• Target on National Project •
Effect of Jujuboside B on Voltage-Gated Sodium Channels in Rat Ventricular Myocytes
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Xiaona DONG1, 2, Jie XIANG3, 4, Ye ZHU2, Shengzhan PENG3, Zhengxin XU3, 4, 5, Xiang GU2
Affiliations
  • 1.Clinical Medical College，Yangzhou University，Yangzhou 225009，Jiangsu，China
  • 2.Northern Jiangsu People's Hospital Affiliated to Yangzhou University，Yangzhou 225001，Jiangsu，China
  • 3.Department of Pharmacology，School of Medicine，Yangzhou University，Yangzhou 225009，Jiangsu，China
  • 4.Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases，Yangzhou University，Yangzhou 225001，Jiangsu，China
  • 5.Jiangsu Key Laboratory of Experimental & Translational Non-Coding RNA Research，Yangzhou 225009，Jiangsu，China
Published: 2025-12-10 doi: 10.13193/j.issn.1673-7717.2025.12.009
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Jujuboside B（JuB），one of themain constituents of herbal medicine Suanzaoren（Ziziphi Spinosae Semen），possess various pharmacological activities，including anti-inflammatory，antiplatelet and anti-restenosis potentials on the cardiovascular system.However，anti-arrhythmia and underlying mechanisms of JuB are uncertain.This study explored the effects of JuB on the sodium currents（INa）in rat ventricular myocytes using whole-cell patch-clamp techniques and molecular docking studies.The whole-cell patch-clamp technique showed that the current-voltage（Ⅰ-Ⅴ）curves of INa shifted along the positive axis in a dose-dependent manner with JuB.Besides，the administration of JuB caused the steady-state activation curve to shift positively along the voltage axis，i.e.，a depolarization trend but the steady-state inactivation curve of INa shifted negatively，which represented that JuB suppressed the opening process of the Na+channel and may had a strong affinity for binding to sodium channels during inactivation.Themolecular docking study exhibited that JuB was mainly docked in the trans membrane helices of voltage-sensing domain（VSD）ⅢandⅣ of rNav1.5 and rNav1.5/QQQ.The study preliminarily confirmed that JuB can inhibited voltage-gated sodium channel of cardiacmyocytes for the first time.

Jujuboside B  /  cardiac myocytes  /  voltage-gated sodium channel  /  molecular docking  /  arrhythmia
Xiaona DONG, Jie XIANG, Ye ZHU, Shengzhan PENG, Zhengxin XU, Xiang GU. Effect of Jujuboside B on Voltage-Gated Sodium Channels in Rat Ventricular Myocytes[J]. Chinese Archives of Traditional Chinese Medicine, 2025 , 43 (12) : 55 -59 . DOI: 10.13193/j.issn.1673-7717.2025.12.009
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Year 2025 volume 43 Issue 12
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doi: 10.13193/j.issn.1673-7717.2025.12.009
  • Online Date：2026-04-29
  • Published：2025-12-10
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Affiliations
    1.Clinical Medical College，Yangzhou University，Yangzhou 225009，Jiangsu，China
    2.Northern Jiangsu People's Hospital Affiliated to Yangzhou University，Yangzhou 225001，Jiangsu，China
    3.Department of Pharmacology，School of Medicine，Yangzhou University，Yangzhou 225009，Jiangsu，China
    4.Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases，Yangzhou University，Yangzhou 225001，Jiangsu，China
    5.Jiangsu Key Laboratory of Experimental & Translational Non-Coding RNA Research，Yangzhou 225009，Jiangsu，China
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https://castjournals.cast.org.cn/joweb/zhzyyxk/EN/10.13193/j.issn.1673-7717.2025.12.009
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表12种不同金属材料的力学参数
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Family		 属数
Number of
genus		 种数
Number of
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Percentage of
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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