To observe the clinical efficacy of Wangbi Capsule（尪痹胶囊）in the treatment of dampness-heat blocking collateral type of rheumatoid arthritis and its effects on serum granulocyte-macrophage colony-stimulating factor（GM-CSF），tumor necrosis factor-α（TNF-α）and CD4⁺T cell subsets.

Ninety-eighty patients with rheumatoid arthritis treated in the Rheumatology and Immunology Department of the hospital from June 2020 to June 2023 were selected as the study objects，and the above patients were divided into control group and observation group with 49 cases in each group by random number table method.The control group was given leflunomide orally，and the observation group was given Wangbi Capsule on the basis of the control group.The clinical efficacy，TCM syndrome score and adverse reactions，the degree of joint pain and the levels of serum inflammatory factors before and after treatment were compared between two groups.

The effective rate of the control group was 79.59%，and that of the observation group was 93.88%.Compared with that of the control group，the effective rate of the observation group was significantly increased（P<0.05）.There was no significant difference in TCM syndrome scores between the two groups before treatment（P>0.05）.After treatment，the levels of morning stiffness，joint flexion and extension，fever，joint swelling pain and heat in the observation group were significantly decreased compared with those in the control group（P<0.01）.Before intervention，there was no significant difference in ultrasound scores between the two groups（P>0.05）.After the intervention，the ultrasound scores in the observation group were significantly higher than those in the control group（P<0.05）.Before intervention，there was no significant difference in the degree of joint pain between the two groups（P>0.05）.Compared with those of the control group，visual analog scale（VAS）score and disease activity score 28（DAS28）score of the observation group were significantly decreased after treatment（P<0.01）.There was no significant difference in serum inflammatory factors between the two groups before intervention（P>0.05）.After the intervention，the levels of erythrocyte sedimentation rate（ESR），C-reactive protein（CRP），rheumatoid factor（RF），GM-CSF and TNF-αin the observation group were significantly decreased compared with those in the control group（P<0.01）.During the intervention，the main adverse reactions of all patients were gastrointestinal discomfort，hemocytopenia，elevated aminotransferase and skin allergy，and there was no significant difference in the incidence of adverse reactions between the two groups（P>0.05）.

Wangbi Capsule combined with leflunomide has a good clinical effect in the treatment of moisture-heat blocking collateral type of rheumatoid arthritis，which can alleviate the joint pain and dysfunction，improve the jointultrasound status and inhibit the inflammation，without increasing the adverse reactions.