To study the clinical study of Jingu Tongxiao Pill（筋骨痛消丸）combined with arthroscopy in the treatment of knee osteoarthritis（cold coagulation blood stasis syndrome）.

A total of 120 patients diagnosed as knee osteoarthritis（cold coagulation and blood stasis syndrome）were selected and divided into two groups according to random number table.The reference group（60 cases）received arthroscopic treatment，and the study group（60 cases）received Jingu Tongxiao Pill and arthroscopic treatment.The clinical efficacy，TCM syndrome score，osteoarthritis index，inflammatory factor level and oxidative stress reaction of the two groupswere observed and compared.

Compared with that（75.00%）of the reference group，the total effective rate of the study group was98.33%，and the difference was statistically significant（P<0.05）.After treatment，the TCM syndrome score of the study group was lower than that of the reference group，and the difference was statistically significant（P<0.05）.After treatment，compared with those of the reference group，the pain，stiffness and difficulty scores of daily activities in the study group were lower，and the difference was statistically significant（P<0.05）.After treatment，compared with those of the reference group，the levels of tumor necrosis factor-alpha（TNF-α），interleukin-1 beta（IL-1β）and matrixmetalloproteinase-3（MMP-3）in the study group were lower，and the difference was statistically significant（P<0.05）.

The patients with knee osteoarthritis（cold coagulation blood stasis syndrome）were treated with arthroscopy and Jingu Tongxiao Pill，and the therapeutic effect was good，which could effectively improve the clinical symptoms and promote the recovery of patients，and the clinical application value was high.