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To investigate the correlation between different types of refractory peptic ulcer（RPU）and clinical manifestations，and to provide clinical basis for the prevention and treatment of this disease in modern medicine.
A crosssectional study was conducted to retrospectively collect the general data，clinical medical records，tongue and pulse conditions，TCM syndromes and other related factors of130 patients with RPU who were hospitalized in the Department of Gastroenterology of Zhengzhou People's Hospital from January 1，2020 to September30，2023.The collected data was statistically analyzed to explore the relationship between different types of RPU and clinical manifestations.
（1）There was no significant difference between the types of RPU and the distribution of tongue and pulse.（2）In terms of disease location syndrome elements，the mostusual disease location syndrome elements of RPU were heart and stomach（100.00%），the others were spleen（43.08%）and liver（30.00%）；in terms of disease nature syndrome elements，the most usual disease nature syndrome elements were spleen and stomach weakness（cold）syndrome（28.46%），followed by liver-stomach disharmony syndrome（21.54%），blood stasis in stomach collateral syndrome（16.15%），damp-heat in spleen and stomach syndrome（14.62%），stomach Yin deficiency syndrome（10.77%），liver-stomach heat stagnation syndrome（8.46%）.（3）There was no significant difference in hypertension，coronary heart disease and weight among the three groups（P>0.05）.There were significant differences in gender，Helicobacter pylori（Hp）infection，smoking history，diabetes，age，height and oral non-steroidal anti-inflammatory drugs（NSAIDs）（P<0.05）.Oralad ministration of NSAIDs is a risk factor for refractory compound ulcer and refractory duodenalulcer.Coronary heart disease，height and Hp infection are risk factors for refractory gastric ulcer.
The patients with Hp infection have a higher probability of refractory gastric ulcer.The patients with smoking history，diabetes and NSAIDs are more likely to develop refractory duodenal ulcer.Patients with different ages and heights are prone to RPU types.Oral administration of NSAIDs is a risk factor for refractory compound ulcer and refractory duodenal ulcer.Coronary heart disease，height and Hp infection are risk factors for RPU.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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