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Study on Anti-SARS-CoV-2 Mechanism of Emodin and Prediction of Antiviral Activity of Anthraquinone Compounds
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Jingfang LIU1, Qian LIU2, Yingnan ZHAO3, Lei YANG3, Yujia WANG4, Jianyuan ZHAO4, Yanlei SU3, Dianxing SUN3, Shan CEN4
Chinese Archives of Traditional Chinese Medicine | 2026, 44(9) : 202 - 205
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Chinese Archives of Traditional Chinese Medicine | 2026, 44(9): 202-205
• Target on National Project •
Study on Anti-SARS-CoV-2 Mechanism of Emodin and Prediction of Antiviral Activity of Anthraquinone Compounds
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Jingfang LIU1, Qian LIU2, Yingnan ZHAO3, Lei YANG3, Yujia WANG4, Jianyuan ZHAO4, Yanlei SU3, Dianxing SUN3, Shan CEN4
Affiliations
  • 1.Hebei Province Academy of Chinese Medicine Sciences, Shijiazhuang 050030, Hebei, China
  • 2.Youfu Hospital of Hebei Province, Shijiazhuang 050051, Hebei, China
  • 3.The 980th Hospital of the Joint Logistics Support Force of the Chinese People's Liberation Army, Shijiazhuang 050082, Hebei, China
  • 4.Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, Hebei, China
Published: 2026-09-10 doi: 10.13193/j.issn.1673-7717.2026.09.036
Outline
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Objective

To study the inhibitory effect of emodin on SARS-CoV-2 RNA polymerase (RdRp) and main protease (Mpro) and predict the anti-SARS-CoV-2 activity of anthraquinone compounds.

Methods

A cell-level SARS-CoV-2 RNA polymerase catalytic reaction system was used to detect the inhibitory activity of emodin against RdRp. An in vitro fluorescence polarization model was used to test the inhibitory activity of emodin against SARS-CoV-2 Mpro. Molecular docking technology was used to study the binding mode of anthraquinone compounds at the active site of RdRp.

Results

The experiment showed that emodin inhibited RdRp with inhibition rates of 42.01%±3.43%, 47.28%±11.20% and 84.28%±4.34% at concentrations of 10, 25, 50 μmol/L, respectively. It did not show significant inhibitory activity against Mpro at drug concentrations of 25, 50, 100 μmol/L. Anthraquinone compounds can occupy the NTPs channel of the target enzyme, thereby hindering the entry of substrate molecules.

Conclusion

This experiment confirmed that emodin has a significant inhibitory effect on SARS-CoV-2 RNA polymerase. The small molecule anthraquinone compounds in this paper should have strong anti-SARS-CoV-2 activity.

SARS-CoV-2  /  RNA polymerase  /  main protease  /  molecular docking  /  activity test  /  emodin  /  anthraquinone
刘京芳, 刘倩, 赵英男, 杨雷, 王宇佳, 赵建元, 苏彦雷, 孙殿兴, 岑山. 大黄素抗新型冠状病毒机制研究及蒽醌类化合物抗病毒活性预测. 中华中医药学刊, 2026 , 44 (9) : 202 -205 . DOI: 10.13193/j.issn.1673-7717.2026.09.036
Jingfang LIU, Qian LIU, Yingnan ZHAO, Lei YANG, Yujia WANG, Jianyuan ZHAO, Yanlei SU, Dianxing SUN, Shan CEN. Study on Anti-SARS-CoV-2 Mechanism of Emodin and Prediction of Antiviral Activity of Anthraquinone Compounds[J]. Chinese Archives of Traditional Chinese Medicine, 2026 , 44 (9) : 202 -205 . DOI: 10.13193/j.issn.1673-7717.2026.09.036
Appendix
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Year 2026 volume 44 Issue 9
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Article Info
doi: 10.13193/j.issn.1673-7717.2026.09.036
  • Online Date：2026-10-20
  • Published：2026-09-10
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Affiliations
    1.Hebei Province Academy of Chinese Medicine Sciences, Shijiazhuang 050030, Hebei, China
    2.Youfu Hospital of Hebei Province, Shijiazhuang 050051, Hebei, China
    3.The 980th Hospital of the Joint Logistics Support Force of the Chinese People's Liberation Army, Shijiazhuang 050082, Hebei, China
    4.Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, Hebei, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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