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Research Progress of Huangqi (Astragali Radix) Active Ingredient in Treating Diabetic Kidney Disease Based on “Treating Qi First for Treating Water”
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Jiawei ZHANG1, 2, Zhifen ZHAO1, 2, Xiangge REN1, 2, Jianye REN1, 2, Tengfei SONG1, 2, Shoudao LI1, 2, Wensheng ZHAI1, 2
Chinese Archives of Traditional Chinese Medicine | 2026, 44(7) : 131 - 136
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Chinese Archives of Traditional Chinese Medicine | 2026, 44(7): 131-136
• Target on National Project •
Research Progress of Huangqi (Astragali Radix) Active Ingredient in Treating Diabetic Kidney Disease Based on “Treating Qi First for Treating Water”
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Jiawei ZHANG1, 2, Zhifen ZHAO1, 2, Xiangge REN1, 2, Jianye REN1, 2, Tengfei SONG1, 2, Shoudao LI1, 2, Wensheng ZHAI1, 2
Affiliations
  • 1.Pediatric Hospital, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450000, Henan, China
  • 2.College of Pediatrics, Henan University of Chinese Medicine, Zhengzhou 450000, Henan, China
Published: 2026-07-10 doi: 10.13193/j.issn.1673-7717.2026.07.024
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Diabetic kidney disease (DKD) is one of the common microvascular complications of diabetes mellitus (DM), and also one of the main causes of chronic kidney disease (CKD) and end-stage renal disease (ESRD). In recent years, traditional Chinese medicine has played an important role in the treatment and prevention of DKD. Based on the theory of “treating Qi first for treating water”, the author explored the main mechanism of the holy medicine Huangqi (Astragali Radix) and its active ingre-dients in the treatment of DKD. Studies have shown that Huangqi (Astragali Radix) and its active ingredients, such as total Astragalus flavones (TFA), calycosin, Astragaloside Ⅳ (AS-Ⅳ) and Astragalus polysaccharide (APS), can be prevented by improving insulin resistance, inhibiting oxidative stress, anti-inflammation, delaying renal fibrosis, anti-apoptosis, inhibiting iron death, regulating autophagy, regulating intestinal flora and so on to treat DKD, in order to provide new drug ideas and methods for TCM treatment of DKD.

Huangqi (Astragali Radix)  /  diabetic kidney disease  /  active ingredients  /  Astragaloside Ⅳ  /  Astragalus polysaccharide
张佳伟, 赵志芬, 任相阁, 任建业, 宋腾飞, 李首道, 翟文生. 基于“治水者必先治气”探讨黄芪活性成分治疗糖尿病肾病的研究进展. 中华中医药学刊, 2026 , 44 (7) : 131 -136 . DOI: 10.13193/j.issn.1673-7717.2026.07.024
Jiawei ZHANG, Zhifen ZHAO, Xiangge REN, Jianye REN, Tengfei SONG, Shoudao LI, Wensheng ZHAI. Research Progress of Huangqi (Astragali Radix) Active Ingredient in Treating Diabetic Kidney Disease Based on “Treating Qi First for Treating Water”[J]. Chinese Archives of Traditional Chinese Medicine, 2026 , 44 (7) : 131 -136 . DOI: 10.13193/j.issn.1673-7717.2026.07.024
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Year 2026 volume 44 Issue 7
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doi: 10.13193/j.issn.1673-7717.2026.07.024
  • Online Date：2026-10-20
  • Published：2026-07-10
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    1.Pediatric Hospital, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450000, Henan, China
    2.College of Pediatrics, Henan University of Chinese Medicine, Zhengzhou 450000, Henan, China
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表12种不同金属材料的力学参数
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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