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Study on Inhibitory Pharmacological Activity of Psoralen against SARS-CoV-2 Main Protease and RNA Polymerase
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Pengfei HAN1, Yanlei SU2, Dianxing SUN2, Jing ZHANG3, Qian LIU4
Chinese Archives of Traditional Chinese Medicine | 2026, 44(7) : 65 - 67
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Chinese Archives of Traditional Chinese Medicine | 2026, 44(7): 65-67
• Target on National Project •
Study on Inhibitory Pharmacological Activity of Psoralen against SARS-CoV-2 Main Protease and RNA Polymerase
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Pengfei HAN1, Yanlei SU2, Dianxing SUN2, Jing ZHANG3, Qian LIU4
Affiliations
  • 1.Hebei Eye Hospital, Xingtai 054001, Hebei, China
  • 2.The 980th Hospital of the Joint Logistics Support Force of the Chinese People's Liberation Army, Shijiazhuang 050082, Hebei, China
  • 3.Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
  • 4.Youfu Hospital of Hebei Province, Shijiazhuang 050051, Hebei, China
Published: 2026-07-10 doi: 10.13193/j.issn.1673-7717.2026.07.013
Outline
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Objective

To explore the inhibitory activity of psoralen against SARS-CoV-2 main protease (Mpro) and RNA polymerase (RdRp).

Methods

Crystal structures of Mpro and RdRp were obtained. Molecular docking technology was employed to study the interaction mode of psoralen with the active sites of both enzymes. The inhibitory activity of psoralen against Mpro was tested using an in vitro fluorescence polarization model, while the inhibitory activity against RdRp was tested using a cell-level SARS-CoV-2 RNA polymerase catalytic reaction system.

Results

Psoralen could enter the active sites of Mpro and RdRp and interact with surrounding amino acids, with the binding process releasing free energy of-5.8 kcal/mol and-7.8 kcal/mol, respectively. In the Mpro fluorescence polarization model test, psoralen showed no inhibitory activity against the target enzyme at concentrations of 50, 100 and 200 μmol/L. In the RdRp inhibition test, psoralen showed inhibition rates of 7.36%±4.26%, 16.82%±6.04% and 46.07%±9.01% at concentrations of 10, 25 and 50 μmol/L, respectively.

Conclusion

The small molecule psoralen has no inhibitory activity against Mpro, but has certain inhibitory activity against RdRp.

SARS-CoV-2  /  main protease  /  RNA polymerase  /  psoralen  /  molecular docking  /  activity test
韩鹏飞, 苏彦雷, 孙殿兴, 张晶, 刘倩. 补骨脂素对新型冠状病毒主蛋白酶及RNA聚合酶抑制药理活性的研究. 中华中医药学刊, 2026 , 44 (7) : 65 -67 . DOI: 10.13193/j.issn.1673-7717.2026.07.013
Pengfei HAN, Yanlei SU, Dianxing SUN, Jing ZHANG, Qian LIU. Study on Inhibitory Pharmacological Activity of Psoralen against SARS-CoV-2 Main Protease and RNA Polymerase[J]. Chinese Archives of Traditional Chinese Medicine, 2026 , 44 (7) : 65 -67 . DOI: 10.13193/j.issn.1673-7717.2026.07.013
Appendix
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Year 2026 volume 44 Issue 7
73
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doi: 10.13193/j.issn.1673-7717.2026.07.013
  • Online Date：2026-10-20
  • Published：2026-07-10
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Affiliations
    1.Hebei Eye Hospital, Xingtai 054001, Hebei, China
    2.The 980th Hospital of the Joint Logistics Support Force of the Chinese People's Liberation Army, Shijiazhuang 050082, Hebei, China
    3.Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
    4.Youfu Hospital of Hebei Province, Shijiazhuang 050051, Hebei, China
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https://castjournals.cast.org.cn/joweb/zhzyyxk/EN/10.13193/j.issn.1673-7717.2026.07.013
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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