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Eye-Image Features of Patients with Coronary Heart Disease Assessed by Combination of Traditional Chinese and Western Medicine: A Retrospective Study
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Zhanqun GAO1, 2, 3, Dirui ZHANG2, 3, Sining HU2, 3, Ziqian WENG2, 3, Minghao LIU2, 3, Yubo GAO2, 3, Wei HAO2, 3, Chen ZHAO2, 3, Ming ZENG2, 3, Xue FENG2, 3, Yuhan QIN2, 3, Yishuo XU2, 3, Haibo JIA2, 3, Zhi ZHANG4, 5, Chao FANG2, 3, Bo YU2, 3
Chinese Archives of Traditional Chinese Medicine | 2026, 44(7) : 35 - 39
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Chinese Archives of Traditional Chinese Medicine | 2026, 44(7): 35-39
• Target on National Project •
Eye-Image Features of Patients with Coronary Heart Disease Assessed by Combination of Traditional Chinese and Western Medicine: A Retrospective Study
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Zhanqun GAO1, 2, 3, Dirui ZHANG2, 3, Sining HU2, 3, Ziqian WENG2, 3, Minghao LIU2, 3, Yubo GAO2, 3, Wei HAO2, 3, Chen ZHAO2, 3, Ming ZENG2, 3, Xue FENG2, 3, Yuhan QIN2, 3, Yishuo XU2, 3, Haibo JIA2, 3, Zhi ZHANG4, 5, Chao FANG2, 3, Bo YU2, 3
Affiliations
  • 1.General Hospital of Hunan University of Medicine, Huaihua 418000, Hunan, China
  • 2.The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, Heilongjiang, China
  • 3.The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin 150086, Heilongjiang, China
  • 4.National Engineering Research Center for Beijing Biochip Technology, Beijing 102206, China
  • 5.Capital Bio Corporation, Beijing 102206, China
Published: 2026-07-10 doi: 10.13193/j.issn.1673-7717.2026.07.007
Outline
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Objective

It aimed to investigate the potential causal relationship between eye-image features and CHD, as examined by coronary angiography (CAG).

Methods

The study selected the patients hospitalized in the Department of Cardiology from November 15, 2021 to February 27, 2022. The selected patients were divided into two groups based on their CAG findings: the CHD group (at least one coronary lesion stenosis≥50%) and the control group (lesion stenosis<50%).

Results

The final analysis included 342 patients out of a total of 426 participants, and 165 (48.2%) were diagnosed with CHD among these participants. The study found that certain characteristics in the left region 5 (L5) and right region (R5) were associated with CHD, including L5 pink dark speckle (OR: 4.143, 95%CI[1.135, 15.124], P=0.031), L5 vascular tortuosity (OR: 0.234, 95%CI[0.077, 0.71], P=0.010), R5 dark red blood vessels (known as blood meridian in TCM)(OR: 1.683, 95%CI[1.035, 2.738], P=0.036) and R5 yellowish mounds (OR: 2.083, 95%CI[1.221, 3.554], P=0.007). Multivariate regression analyses showed that L5 vascular tortuosity had a negative correlation with CHD.

Conclusion

The study revealed that four types of eye-image features, namely pink dark speckle, vascular tortuosity, dark red blood vessels and yellowish mounds, were associated with CHD. A-mong these features, vascular tortuosity showed a negative correlation with CHD, which could potentially aid in the diagnosis of the disease.

eye-image  /  coronary heart disease  /  traditional Chinese medicine
高占群, 张迪瑞, 胡思宁, 翁子骞, 刘明皓, 高语博, 郝伟, 赵晨, 曾明, 冯雪, 秦雨涵, 徐艺硕, 贾海波, 张智, 房超, 于波. 冠心病患者的眼像特征：一项中医结合现代医学的前瞻性观察研究. 中华中医药学刊, 2026 , 44 (7) : 35 -39 . DOI: 10.13193/j.issn.1673-7717.2026.07.007
Zhanqun GAO, Dirui ZHANG, Sining HU, Ziqian WENG, Minghao LIU, Yubo GAO, Wei HAO, Chen ZHAO, Ming ZENG, Xue FENG, Yuhan QIN, Yishuo XU, Haibo JIA, Zhi ZHANG, Chao FANG, Bo YU. Eye-Image Features of Patients with Coronary Heart Disease Assessed by Combination of Traditional Chinese and Western Medicine: A Retrospective Study[J]. Chinese Archives of Traditional Chinese Medicine, 2026 , 44 (7) : 35 -39 . DOI: 10.13193/j.issn.1673-7717.2026.07.007
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Year 2026 volume 44 Issue 7
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Article Info
doi: 10.13193/j.issn.1673-7717.2026.07.007
  • Online Date：2026-10-20
  • Published：2026-07-10
Article Data
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Affiliations
    1.General Hospital of Hunan University of Medicine, Huaihua 418000, Hunan, China
    2.The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, Heilongjiang, China
    3.The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin 150086, Heilongjiang, China
    4.National Engineering Research Center for Beijing Biochip Technology, Beijing 102206, China
    5.Capital Bio Corporation, Beijing 102206, China
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