Chronic cough is the most common complaint in respiratory clinics and community outpatient departments. Chronic refractory cough is often treated repeatedly due to the persistence and recurrence of cough symptoms, which has become a difficult problem to be solved urgently in clinical practice. This article explored the pathogenesis evolution and therapeutic approaches of chronic refractory cough based on the theory of “Qi deficiency inducing retention and stagnation”. It holds that “Qi deficiency” is the internal basis for the onset of chronic refractory cough. According to the characteristics of the development of the pathogenesis stage, it can be divided into the beginning of the disease-deficiency of primary Qi and lung Yin, the gradual progression of the disease-deficiency of spleen Yang and failure of regulation, and the severe stage of the disease-deficiency of kidney essence and damage to the lung and spleen. The “retention and stagnation” of pathogenic factors such as phlegm-dampness, blood stasis and latent wind is the key pathological factor in the onset of chronic refractory cough. The retention of various pathogenic factors, ascending to the lung, causes upward rebellion of lung Qi, aggravating cough and leading to prolonged illness. The therapeutic approach should be based on the fundamental principles of tonifying deficiency and dredging stagnation, and commonly used treatment methods include nourishing lung Yin, warming spleen Yang, tonifying kidney essence, expelling latent wind, eliminating coagulation stasis, and resolving phlegm and dampness, with the aim of providing a reference for precise treatment of chronic refractory cough in clinical practice.
| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |